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    Slik Sterile20-like kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37893, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slikprovided by FlyBase
    Official Full Name
    Sterile20-like kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035001
    Locus tag
    Dmel_CG4527
    See related
    AllianceGenome:FB:FBgn0035001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4527; Dmel\CG4527; dPlkk; dPlkk/Slik; DPlkk1; Plkk/Slik; Plkk1; PLKK1; slik; SLIK; Slik1; slk; Slk; SLK
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including cytoskeleton organization; metaphase/anaphase transition of mitotic cell cycle; and rhabdomere membrane biogenesis. Located in several cellular components, including cleavage furrow; mitotic spindle midzone; and rhabdomere. Is expressed in adult head and spermatozoon. Orthologous to several human genes including SLK (STE20 like kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Slik in Genome Data Viewer
    Location:
    60C7-60C8; 2-106 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24392129..24402680, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20279652..20290203, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene muscarinic Acetylcholine Receptor, A-type Neighboring gene long non-coding RNA:CR44813 Neighboring gene Regulatory particle non-ATPase 8 Neighboring gene Serotonin transporter Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class Z

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila orthologue of xPlkk1 is not essential for Polo activation and is necessary for proper contractile ring formation. Alves PS, et al. Exp Cell Res, 2006 Feb 1. PMID 16337190
    2. Phosphorylation and activity of the tumor suppressor Merlin and the ERM protein Moesin are coordinately regulated by the Slik kinase. Hughes SC, et al. J Cell Biol, 2006 Oct 23. PMID 17060498, Free PMC Article
    3. Slik phosphorylation of Talin T152 is crucial for proper Talin recruitment and maintenance of muscle attachment in Drosophila. Katzemich A, et al. Development, 2019 Oct 3. PMID 31511253
    4. The Ste20-like kinase - a Jack of all trades? Garland B, et al. J Cell Sci, 2021 May 1. PMID 33961052
    5. PP1-mediated moesin dephosphorylation couples polar relaxation to mitotic exit. Kunda P, et al. Curr Biol, 2012 Feb 7. PMID 22209527

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The conserved C-terminal coiled-coil domain of Slik, which is necessary and sufficient for apical localization of the kinase in epithelial cells, is not required for Moesin phosphorylation but is critical for the growth-promoting function of Slik.
      Title: Regulation of Catalytic and Non-catalytic Functions of the Drosophila Ste20 Kinase Slik by Activation Segment Phosphorylation.
    2. Slik acts via distinct pathways to coordinate cell proliferation with epithelial cell behavior during tissue growth.
      Title: Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth.
    3. Slik mediates growth and survival cues to promote cell proliferation and control cell survival during Drosophila development
      Title: The Drosophila sterile-20 kinase slik controls cell proliferation and apoptosis during imaginal disc development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in branching involved in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metaphase/anaphase transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhabdomere membrane biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rhabdomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sterile20-like kinase
    Names
    CG4527-PA
    CG4527-PB
    CG4527-PD
    CG4527-PE
    CG4527-PF
    CG4527-PG
    Slik-PA
    Slik-PB
    Slik-PD
    Slik-PE
    Slik-PF
    Slik-PG
    Ste20 kinase
    Sterile-20
    dPlkk/Slik threonine kinase
    polo kinase kinase 1
    sterile 20-like kinase
    NP_001014549.1
    NP_001137752.1
    NP_611908.2
    NP_726441.1
    NP_995935.1
    NP_995936.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24392129..24402680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166669.4 → NP_726441.1  Sterile20-like kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726441.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W179
      Related
      FBpp0072271
      Conserved Domains (3) summary
      cd06611
      Location:31 → 310
      STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
      smart00220
      Location:37 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:1126 → 1266
      PKK; Polo kinase kinase

    2. NM_206214.4 → NP_995936.2  Sterile20-like kinase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995936.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZU8, Q7YZB2
      Conserved Domains (3) summary
      cd06611
      Location:31 → 310
      STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
      smart00220
      Location:37 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:1140 → 1280
      PKK; Polo kinase kinase

    3. NM_206213.3 → NP_995935.1  Sterile20-like kinase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995935.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W179
      Conserved Domains (3) summary
      cd06611
      Location:31 → 310
      STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
      smart00220
      Location:37 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:1126 → 1266
      PKK; Polo kinase kinase

    4. NM_001014549.3 → NP_001014549.1  Sterile20-like kinase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014549.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E61, Q7YZB2
      Conserved Domains (3) summary
      cd06611
      Location:31 → 310
      STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
      smart00220
      Location:37 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:1126 → 1266
      PKK; Polo kinase kinase

    5. NM_001144280.2 → NP_001137752.1  Sterile20-like kinase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZQ1, Q7YZB2
      Conserved Domains (3) summary
      cd06611
      Location:31 → 310
      STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
      smart00220
      Location:37 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:1126 → 1266
      PKK; Polo kinase kinase

    6. NM_138064.4 → NP_611908.2  Sterile20-like kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611908.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZB2, Q8MLP1
      Related
      FBpp0072270
      Conserved Domains (3) summary
      cd06611
      Location:31 → 310
      STKc_SLK_like; Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases
      smart00220
      Location:37 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:1126 → 1266
      PKK; Polo kinase kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4UZU8 A4UZU8
    B7YZQ1 B7YZQ1
    Q59E61 Q59E61
    Q7YZB2 Q7YZB2
    Q8MLP1 Q8MLP1
    Q8MRH6 Q8MRH6
    Q95U41 Q95U41
    Q9W179 Q9W179

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