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    Ppcs Phosphopantothenoylcysteine synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42295, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppcsprovided by FlyBase
    Official Full Name
    Phosphopantothenoylcysteine synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261285
    Locus tag
    Dmel_CG5629
    See related
    AllianceGenome:FB:FBgn0261285
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.401; BcDNA:GH03502; CG5629; Dmel\CG5629; dPPCS; GH03502; PPCS
    Summary
    Enables phosphopantothenate--cysteine ligase activity. Involved in several processes, including dorsal appendage formation; oogenesis; and phospholipid homeostasis. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head; larval midline neurons; midline primordium; and organism. Used to study dilated cardiomyopathy and neurodegenerative disease. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2C. Orthologous to human PPCS (phosphopantothenoylcysteine synthetase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ppcs in Genome Data Viewer
    Location:
    91F3-91F4; 3-66 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19139054..19147910, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14964776..14973632, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 12a5 Neighboring gene Cytochrome P450 12a4 Neighboring gene antisense RNA:CR44107 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nanos

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity. Mostert KJ, et al. ACS Chem Biol, 2021 Nov 19. PMID 34582681, Free PMC Article
    2. The opportunities and challenges of using Drosophila to model human cardiac diseases. Zhao Y, et al. Front Physiol, 2023. PMID 37123266, Free PMC Article
    3. Stress affects the epigenetic marks added by natural transposable element insertions in Drosophila melanogaster. Guio L, et al. Sci Rep, 2018 Aug 15. PMID 30111890, Free PMC Article
    4. Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy. Iuso A, et al. Am J Hum Genet, 2018 Jun 7. PMID 29754768, Free PMC Article
    5. CoA protects against the deleterious effects of caloric overload in Drosophila. Palanker Musselman L, et al. J Lipid Res, 2016 Mar. PMID 26805007, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphopantothenate--cysteine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopantothenate--cysteine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphopantothenate--cysteine ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phospholipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphopantothenoylcysteine synthetase
    Names
    4'-phosphopantothenoylcysteine synthetase
    CG5629-PA
    CG5629-PC
    CG5629-PD
    Ppcs-PA
    Ppcs-PC
    Ppcs-PD
    NP_001303433.1
    NP_650784.3
    NP_732401.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19139054..19147910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169848.3 → NP_732401.1  phosphopantothenoylcysteine synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732401.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KN99
      Related
      FBpp0083166
      Conserved Domains (1) summary
      PRK05579
      Location:26 → 257
      PRK05579; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated

    2. NM_142527.3 → NP_650784.3  phosphopantothenoylcysteine synthetase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650784.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QD26
      Conserved Domains (1) summary
      cl04410
      Location:34 → 257
      DFP; DNA / pantothenate metabolizm flavoprotein

    3. NM_001316504.1 → NP_001303433.1  phosphopantothenoylcysteine synthetase, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KN99
      Conserved Domains (1) summary
      PRK05579
      Location:26 → 257
      PRK05579; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QD26 E2QD26
    Q7KN99 Q7KN99
    Q8T950 Q8T950

    Gene LinkOut

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