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    Cap-D2 CAP-D2 condensin subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43491, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cap-D2provided by FlyBase
    Official Full Name
    CAP-D2 condensin subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039680
    Locus tag
    Dmel_CG1911
    See related
    AllianceGenome:FB:FBgn0039680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cap-D2; CAP-D2; CapD2; CG1911; dCap-D2; DmCAP-D2; Dmel\CG1911
    Summary
    Predicted to enable histone binding activity. Involved in mitotic chromosome condensation. Located in chromatin; cytoplasm; and nucleus. Part of condensin complex. Colocalizes with condensed chromosome, centromeric region. Is expressed in several structures, including antennal primordium; cardiogenic mesoderm; central brain primordium; ganglia; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Cap-D2 in Genome Data Viewer
    Location:
    99B7-99B7; 3-99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29675651..29680257)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25501373..25505979)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Odorant-binding protein 99a Neighboring gene pickpocket 19 Neighboring gene Bub3 Neighboring gene uncharacterized protein Neighboring gene Guanylyl cyclase alpha-subunit at 99B Neighboring gene Odorant-binding protein 99c Neighboring gene doublesex-Mab related 99B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Condensin II subunit dCAP-D3 restricts retrotransposon mobilization in Drosophila somatic cells. Schuster AT, et al. PLoS Genet, 2013 Oct. PMID 24204294, Free PMC Article
    2. Condensin-mediated restriction of retrotransposable elements facilitates brain development in Drosophila melanogaster. Crawford BI, et al. Nat Commun, 2024 Mar 28. PMID 38548759, Free PMC Article
    3. Condensin I is required for faithful meiosis in Drosophila males. Kleinschnitz K, et al. Chromosoma, 2020 Jun. PMID 32314039, Free PMC Article
    4. The condensin I subunit Barren/CAP-H is essential for the structural integrity of centromeric heterochromatin during mitosis. Oliveira RA, et al. Mol Cell Biol, 2005 Oct. PMID 16199875, Free PMC Article
    5. Mutations in mxc Tumor-Suppressor Gene Induce Chromosome Instability in Drosophila Male Meiosis. Tanabe K, et al. Cell Struct Funct, 2019 Oct 23. PMID 31484839

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CAP-D2 is essential for chromosome arm and centromere resolution.
      Title: Drosophila CAP-D2 is required for condensin complex stability and resolution of sister chromatids.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IC
    Inferred by Curator
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of condensin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CAP-D2 condensin subunit
    Names
    CG1911-PA
    Cap-D2-PA
    dCap-D2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29675651..29680257
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143452.3 → NP_651709.1  CAP-D2 condensin subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651709.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAJ1
      Related
      FBpp0084818
      Conserved Domains (3) summary
      COG5098
      Location:85 → 1269
      COG5098; Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      pfam12717
      Location:1091 → 1254
      Cnd1; non-SMC mitotic condensation complex subunit 1
      pfam12922
      Location:77 → 243
      Cnd1_N; non-SMC mitotic condensation complex subunit 1, N-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAJ1 Q9VAJ1

    Gene LinkOut

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