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    kl-2 male fertility factor kl2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355181, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kl-2provided by FlyBase
    Official Full Name
    male fertility factor kl2provided by FlyBase
    Primary source
    FLYBASE:FBgn0001313
    Locus tag
    Dmel_CG17866
    See related
    AllianceGenome:FB:FBgn0001313
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17866; CG40438; DHC3A; Dmel\CG17866; kl2; Lms2
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in flagellated sperm motility. Is active in sperm flagellum. Is expressed in adult head. Human ortholog(s) of this gene implicated in spermatogenic failure 45. Orthologous to human DNAH2 (dynein axonemal heavy chain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kl-2 in Genome Data Viewer
    Location:
    h10-h11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) Y NC_024512.1 (573088..664173)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) YHet NW_001848860.1 (81209..148249)

    Chromosome Y - NC_024512.1Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene male fertility factor kl3 Neighboring gene Aldo-keto reductase on Y Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antimicrobial Properties of a Peptide Derived from the Male Fertility Factor kl2 Protein of Drosophila melanogaster. Bilska B, et al. Curr Issues Mol Biol, 2022 Feb 28. PMID 35723299, Free PMC Article
    2. Extensive introgression of mitochondrial DNA relative to nuclear genes in the Drosophila yakuba species group. Bachtrog D, et al. Evolution, 2006 Feb. PMID 16610321
    3. Structural genes on the Y chromosome of Drosophila melanogaster. Goldstein LS, et al. Proc Natl Acad Sci U S A, 1982 Dec. PMID 6818544, Free PMC Article
    4. Temperature-sensitive mutations in Drosophila melanogaster. XI. Male sterile mutants of the Y chromosome. Ayles GB, et al. Dev Biol, 1973 Jun. PMID 4363872
    5. Surprising differences in the variability of Y chromosomes in African and cosmopolitan populations of Drosophila melanogaster. Larracuente AM, et al. Genetics, 2013 Jan. PMID 23086221, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 617784-618834 mobile_element_type = transposon:1360{}6433
    • Loc: 652433-652804 mobile_element_type = transposon:Stalker3{}6589

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    male fertility factor kl2
    Names
    1beta-dynein heavy chain
    CG17866-PD
    kl-2-PD
    male fertility factor kl-2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_024512.1 Reference assembly

      Range
      573088..664173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001015505.5 → NP_001015505.5  male fertility factor kl2 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0U1RVI8, B4YUS1, Q5LJP0
      Conserved Domains (6) summary
      pfam03028
      Location:3760 → 4447
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:178 → 749
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1244 → 1646
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3043 → 3373
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3402 → 3618
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1785 → 2015
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q281W6 Q281W6
    Q281X0 Q281X0
    Q5LJP0 Q5LJP0
    Q9GPN8 Q9GPN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials