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    CG10474 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37211, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG10474provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034427
    Locus tag
    Dmel_CG10474
    See related
    AllianceGenome:FB:FBgn0034427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10474
    Summary
    Predicted to enable N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in aspartylglucosaminuria and lysosomal storage disease. Orthologous to human AGA (aspartylglucosaminidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10474 in Genome Data Viewer
    Location:
    56C6-56C7; 2-88 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19285395..19286730, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15172900..15174235, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Arylalkylamine N-acetyltransferase-like 5 Neighboring gene Arylalkylamine N-acetyltransferase-like 6 Neighboring gene Arylalkylamine N-acetyltransferase-like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and behavioral analysis of natural variation in Drosophila melanogaster pupation position. Riedl CA, et al. Fly (Austin), 2007 Jan-Feb. PMID 18690058
    2. New genes often acquire male-specific functions but rarely become essential in Drosophila. Kondo S, et al. Genes Dev, 2017 Sep 15. PMID 29051389, Free PMC Article
    3. Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association. Hamilton PT, et al. mBio, 2015 Sep 15. PMID 26374124, Free PMC Article
    4. Molecular and comparative genetics of mental retardation. Inlow JK, et al. Genetics, 2004 Feb. PMID 15020472, Free PMC Article
    5. Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach. Hall BS, et al. Aging (Albany NY), 2019 Dec 3. PMID 31794428, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10474-PA
    NP_611404.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19285395..19286730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137560.2 → NP_611404.1  uncharacterized protein Dmel_CG10474 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611404.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBI7
      Related
      FBpp0085745
      Conserved Domains (1) summary
      cd04513
      Location:1 → 312
      Glycosylasparaginase; Glycosylasparaginase and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBI7 A1ZBI7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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