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    Cpsf5 Cleavage and polyadenylation specific factor 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39083, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cpsf5provided by FlyBase
    Official Full Name
    Cleavage and polyadenylation specific factor 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0288470
    Locus tag
    Dmel_CG3689
    See related
    AllianceGenome:FB:FBgn0288470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdi12; Cdi12; CDI12; CF I[[m]]25; CFI25; CFIm25; CG3689; CPSF5; Dmel\CG3689
    Summary
    Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in mRNA processing. Predicted to be part of mRNA cleavage factor complex. Is expressed in embryonic brain; larval ventral nerve cord; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cpsf5 in Genome Data Viewer
    Location:
    67B5-67B5; 3-29 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9411038..9413835)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9404138..9406737)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 67B Neighboring gene uncharacterized protein Neighboring gene alpha-tubulin acetylase Neighboring gene uncharacterized protein Neighboring gene astray

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction mating reveals binary and ternary connections between Drosophila cell cycle regulators. Finley RL Jr, et al. Proc Natl Acad Sci U S A, 1994 Dec 20. PMID 7809159, Free PMC Article
    2. Isolation of Drosophila cyclin D, a protein expressed in the morphogenetic furrow before entry into S phase. Finley RL Jr, et al. Proc Natl Acad Sci U S A, 1996 Apr 2. PMID 8610160, Free PMC Article
    3. A strategy for constructing large protein interaction maps using the yeast two-hybrid system: regulated expression arrays and two-phase mating. Zhong J, et al. Genome Res, 2003 Dec. PMID 14613974, Free PMC Article
    4. Use of circular RNAs as markers of readthrough transcription to identify factors regulating cleavage/polyadenylation events. Liang D, et al. Methods, 2021 Dec. PMID 33882363, Free PMC Article
    5. Molecular Regulation of Alternative Polyadenylation (APA) within the Drosophila Nervous System. Vallejos Baier R, et al. J Mol Biol, 2017 Oct 27. PMID 28366829, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cleavage and polyadenylation specific factor 5
    Names
    CG3689-PB
    CG3689-PC
    Cpsf5-PB
    Cpsf5-PC
    Cyclin-dependent kinase interactor 12

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9411038..9413835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043132.3 → NP_001036597.1  cleavage and polyadenylation specific factor 5, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036597.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8G6
      Conserved Domains (1) summary
      pfam13869
      Location:45 → 232
      NUDIX_2; Nucleotide hydrolase

    2. NM_140051.3 → NP_648308.1  cleavage and polyadenylation specific factor 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648308.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9F4, Q9VSY2
      Related
      FBpp0076184
      Conserved Domains (1) summary
      pfam13869
      Location:45 → 192
      NUDIX_2; Nucleotide hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8G6 Q0E8G6
    Q9VSY2 Q9VSY2

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