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    Aprt Adenine phosphoribosyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48224, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aprtprovided by FlyBase
    Official Full Name
    Adenine phosphoribosyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000109
    Locus tag
    Dmel_CG18315
    See related
    AllianceGenome:FB:FBgn0000109
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aprt; APRT; BcDNA:LP07986; CG18315; Dmel\CG18315
    Summary
    Predicted to enable AMP binding activity; adenine binding activity; and adenine phosphoribosyltransferase activity. Predicted to be involved in AMP salvage and adenine salvage. Predicted to be active in cytoplasm. Used to study Lesch-Nyhan syndrome. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Aprt in Genome Data Viewer
    Location:
    62B9-62B9; 3-1.0 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1883795..1885019, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1883795..1885019, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene dre4 Neighboring gene uncharacterized protein Neighboring gene Tetraspan membrane protein in hair cell stereocilia Neighboring gene debris buster

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A moveable 5' splice site in adenine phosphoribosyltransferase genes of Drosophila species. Johnson D, et al. Mol Cell Biol, 1989 May. PMID 2501662, Free PMC Article
    2. Cloning of a Drosophila melanogaster adenine phosphoribosyltransferase structural gene and deduced amino acid sequence of the enzyme. Johnson DH, et al. Gene, 1987. PMID 3125085
    3. Adenine phosphoribosyltransferase genes in two Drosophila species: dosage compensation, a nuclear matrix attachment site, and a novel intron position. Johnson DH. Mol Gen Genet, 1993 Apr. PMID 8492806
    4. Purine resistant mutants of Drosophila are adenine phosphoribosyltransferase deficient. Johnson DH, et al. Science, 1981 May 29. PMID 17779974
    5. Purine-resistant Drosophila melanogaster result from mutations in the adenine phosphoribosyltransferase structural gene. Johnson DH, et al. Proc Natl Acad Sci U S A, 1983 May. PMID 6407004, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenine salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenine salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenine phosphoribosyltransferase
    Names
    Aprt-PA
    Aprt-PC
    Aprt-PD
    CG18315-PA
    CG18315-PC
    CG18315-PD
    NP_001286908.1
    NP_001286909.1
    NP_476637.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1883795..1885019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299979.1 → NP_001286908.1  adenine phosphoribosyltransferase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286908.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P12426, Q9W069
      UniProtKB/TrEMBL
      X2J8L3
      Conserved Domains (1) summary
      PRK02304
      Location:9 → 182
      PRK02304; adenine phosphoribosyltransferase; Provisional

    2. NM_001299980.1 → NP_001286909.1  adenine phosphoribosyltransferase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286909.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P12426, Q9W069
      UniProtKB/TrEMBL
      X2J8L3
      Conserved Domains (1) summary
      PRK02304
      Location:9 → 182
      PRK02304; adenine phosphoribosyltransferase; Provisional

    3. NM_057289.3 → NP_476637.1  adenine phosphoribosyltransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476637.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P12426, Q9W069
      UniProtKB/TrEMBL
      X2J8L3
      Related
      FBpp0088438
      Conserved Domains (1) summary
      PRK02304
      Location:9 → 182
      PRK02304; adenine phosphoribosyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12426.3 P12426
    X2J8L3 X2J8L3

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