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    Ubc4 Ubiquitin conjugating enzyme 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39133, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubc4provided by FlyBase
    Official Full Name
    Ubiquitin conjugating enzyme 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0015321
    Locus tag
    Dmel_CG8284
    See related
    AllianceGenome:FB:FBgn0015321
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8284; Dmel\CG8284; E2; UbcD4; UbcD4 E2
    Summary
    Enables proteasome binding activity and ubiquitin protein ligase binding activity. Involved in positive regulation of peptidoglycan recognition protein signaling pathway. Predicted to be active in nucleus. Is expressed in adult head; adult heart; and organism. Orthologous to human UBE2K (ubiquitin conjugating enzyme E2 K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ubc4 in Genome Data Viewer
    Location:
    67C5-67C5; 3-31 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9698336..9700481)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9691436..9693581)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Phosphoribosyl pyrophosphate synthetase Neighboring gene antisense RNA:CR45804 Neighboring gene antisense RNA:CR45121 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UbcD4, a ubiquitin-conjugating enzyme in Drosophila melanogaster expressed in pole cells. Canning M, et al. Mol Genet Genomics, 2002 Feb. PMID 11862484
    2. The Kavar(D) dominant female-sterile mutations of Drosophila reveal a role for the maternally provided alpha-tubulin4 isoform in cleavage spindle maintenance and elongation. Venkei Z, et al. Mol Genet Genomics, 2005 Jun. PMID 15864652
    3. The Gene CG6767 Affects Olfactory Behavior in Drosophila melanogaster. Brown EB, et al. Behav Genet, 2019 May. PMID 30710192
    4. Proteasome, but not autophagy, disruption results in severe eye and wing dysmorphia: a subunit- and regulator-dependent process in Drosophila. Velentzas PD, et al. PLoS One, 2013. PMID 24282550, Free PMC Article
    5. UbcD4, an ortholog of E2-25K/Ube2K, is essential for activation of the immune deficiency pathway in Drosophila. Park ES, et al. Biochem Biophys Res Commun, 2016 Jan 22. PMID 26707646

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We found that UbcD4, in addition to the previously reported E2s Effete and Bendless, was required for activation of the IMD pathway.
      Title: UbcD4, an ortholog of E2-25K/Ube2K, is essential for activation of the immune deficiency pathway in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables proteasome binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin conjugating enzyme 4
    Names
    CG8284-PA
    CG8284-PB
    CG8284-PC
    Ubc4-PA
    Ubc4-PB
    Ubc4-PC
    NP_001287013.1
    NP_001287014.1
    NP_524010.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9698336..9700481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300085.1 → NP_001287014.1  ubiquitin conjugating enzyme 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287014.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52486, P91633
      UniProtKB/TrEMBL
      X2JAX3
      Conserved Domains (2) summary
      cd14391
      Location:163 → 198
      UBA_II_E2_UBCD4; UBA domain found in Drosophila melanogaster ubiquitin-conjugating enzyme E2-22 kDa (UbcD4) and similar proteins
      pfam00179
      Location:8 → 149
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_001300084.1 → NP_001287013.1  ubiquitin conjugating enzyme 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287013.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52486, P91633
      UniProtKB/TrEMBL
      X2JAX3
      Conserved Domains (2) summary
      cd14391
      Location:163 → 198
      UBA_II_E2_UBCD4; UBA domain found in Drosophila melanogaster ubiquitin-conjugating enzyme E2-22 kDa (UbcD4) and similar proteins
      pfam00179
      Location:8 → 149
      UQ_con; Ubiquitin-conjugating enzyme

    3. NM_079286.3 → NP_524010.2  ubiquitin conjugating enzyme 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524010.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52486, P91633
      UniProtKB/TrEMBL
      X2JAX3
      Related
      FBpp0076124
      Conserved Domains (2) summary
      cd14391
      Location:163 → 198
      UBA_II_E2_UBCD4; UBA domain found in Drosophila melanogaster ubiquitin-conjugating enzyme E2-22 kDa (UbcD4) and similar proteins
      pfam00179
      Location:8 → 149
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52486.2 P52486
    X2JAX3 X2JAX3

    Gene LinkOut

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