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    Spn31A Serpin 31A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spn31Aprovided by FlyBase
    Official Full Name
    Serpin 31Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032178
    Locus tag
    Dmel_CG4804
    See related
    AllianceGenome:FB:FBgn0032178
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4804; Dmel\CG4804
    Summary
    Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human SERPINA7 (serpin family A member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spn31A in Genome Data Viewer
    Location:
    31A2-31A2; 2-39 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10060816..10063925)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10060816..10063925)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cuticular protein 31A Neighboring gene Pendulin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
    2. Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation. Bina S, et al. EMBO Rep, 2010 Mar. PMID 20168330, Free PMC Article
    3. Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes. Garrett M, et al. BMC Genomics, 2009 Oct 22. PMID 19849829, Free PMC Article
    4. Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. Xu X, et al. BMC Genomics, 2006 Oct 4. PMID 17020603, Free PMC Article
    5. Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster. Holloway AK, et al. Genome Res, 2008 Oct. PMID 18583644, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables serine-type endopeptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serpin 31A
    Names
    CG4804-PA
    Spn31A-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10060816..10063925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135497.3 → NP_609341.1  serpin 31A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609341.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VL44
      Related
      FBpp0079528
      Conserved Domains (1) summary
      cd00172
      Location:18 → 379
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL44 Q9VL44

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