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    Np Notopleural [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35904, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Npprovided by FlyBase
    Official Full Name
    Notopleuralprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265011
    Locus tag
    Dmel_CG34350
    See related
    AllianceGenome:FB:FBgn0265011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11824; CG34350; CG8181; cSP59; Dmel\CG34350; np; SP59
    Old locus tag
    CG11824; CG8181; Dmel_CG11824; Dmel_CG8181
    Summary
    Enables serine-type peptidase activity. Involved in liquid clearance, open tracheal system. Located in apical plasma membrane and extracellular space. Is expressed in several structures, including embryonic anal pad; embryonic head epidermis; embryonic ventral epidermis; epithelium; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    45A1-45A1; 2-60 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8992945..9006587, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4880450..4894092, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene space blanket Neighboring gene filzig Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic incompatibilities are widespread within species. Corbett-Detig RB, et al. Nature, 2013 Dec 5. PMID 24196712, Free PMC Article
    2. Control of tissue morphogenesis by the HOX gene Ultrabithorax. Diaz-de-la-Loza MD, et al. Development, 2020 Mar 2. PMID 32122911, Free PMC Article
    3. Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis. Drees L, et al. PLoS Genet, 2019 Jan. PMID 30601807, Free PMC Article
    4. Spatiotemporal remodeling of extracellular matrix orients epithelial sheet folding. Tsuboi A, et al. Sci Adv, 2023 Sep. PMID 37656799, Free PMC Article
    5. CopyCatchers are versatile active genetic elements that detect and quantify inter-homolog somatic gene conversion. Li Z, et al. Nat Commun, 2021 May 11. PMID 33976171, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we demonstrate that Tpr zymogen and the ZP domain of the ECM protein Piopio are cleaved by Np and matriptase in vitro.
      Title: Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables serine-type peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in liquid clearance, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    notopleural
    Names
    CG34350-PA
    CG34350-PB
    Np-PA
    Np-PB
    NP_001246213.1
    NP_610437.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8992945..9006587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259284.2 → NP_001246213.1  notopleural, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7M3
      Conserved Domains (2) summary
      smart00020
      Location:797 → 1035
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:798 → 1038
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_136593.3 → NP_610437.2  notopleural, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610437.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7M3
      Conserved Domains (2) summary
      smart00020
      Location:797 → 1035
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:798 → 1038
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7M3 A1Z7M3

    Gene LinkOut

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