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    Cyp12a4 Cytochrome P450 12a4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42294, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp12a4provided by FlyBase
    Official Full Name
    Cytochrome P450 12a4provided by FlyBase
    Primary source
    FLYBASE:FBgn0038681
    Locus tag
    Dmel_CG6042
    See related
    AllianceGenome:FB:FBgn0038681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    12a4; CG6042; cyp12a4; Cyp12A4; CYP12A4; Dmel\CG6042; P450; Rst(Luf)
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in response to insecticide. Is expressed in adult head; adult heart; embryonic/larval Malpighian tubule; embryonic/larval midgut; and gastric caecum. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp12a4 in Genome Data Viewer
    Location:
    91F3-91F3; 3-66 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19135158..19137136)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14960880..14962858)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12a5 Neighboring gene Phosphopantothenoylcysteine synthetase Neighboring gene antisense RNA:CR44107 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for a functional interaction between the Bari1 transposable element and the cytochrome P450 cyp12a4 gene in Drosophila melanogaster. Marsano RM, et al. Gene, 2005 Sep 12. PMID 16076534
    2. Resistance and the jumping gene. ffrench-Constant R, et al. Bioessays, 2006 Jan. PMID 16369944
    3. Evidence for activation of nitenpyram by a mitochondrial cytochrome P450 in Drosophila melanogaster. Harrop TW, et al. Pest Manag Sci, 2018 Jul. PMID 29316188
    4. Stress affects the epigenetic marks added by natural transposable element insertions in Drosophila melanogaster. Guio L, et al. Sci Rep, 2018 Aug 15. PMID 30111890, Free PMC Article
    5. Effects of benzoylphenylurea on chitin synthesis and orientation in the cuticle of the Drosophila larva. Gangishetti U, et al. Eur J Cell Biol, 2009 Mar. PMID 18996617

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to insecticide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 12a4
    Names
    CG6042-PA
    Cyp12a4-PA
    cytochrome P450
    NP_650783.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19135158..19137136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142526.4 → NP_650783.2  cytochrome P450 12a4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650783.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B8A3W5, Q461P8, Q5CAL0, Q6A1J1, Q6A1J2, Q8SZL9, Q9VE00
      Related
      FBpp0083145
      Conserved Domains (1) summary
      cl12078
      Location:72 → 531
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VE00.2 Q9VE00

    Gene LinkOut

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