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    MetRS-m Methionyl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41733, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MetRS-mprovided by FlyBase
    Official Full Name
    Methionyl-tRNA synthetase, mitochondrialprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027083
    Locus tag
    Dmel_CG31322
    See related
    AllianceGenome:FB:FBgn0027083
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aats-met; Aats-Met; Aats-met-m; CG31322; CG8684; CG9612; dMARS; Dmel\CG31322; MetRS; MRS
    Summary
    Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in methionyl-tRNA aminoacylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Used to study mitochondrial metabolism disease and neurodegenerative disease. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 25 and spastic ataxia 3. Orthologous to human MARS2 (methionyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MetRS-m in Genome Data Viewer
    Location:
    88B1-88B1; 3-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14249043..14259991, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10077105..10085713, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. Bayat V, et al. PLoS Biol, 2012. PMID 22448145, Free PMC Article
    2. Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina. Van Den Brink DM, et al. PLoS Genet, 2018 Sep. PMID 30199545, Free PMC Article
    3. 'Fly-ing' from rare to common neurodegenerative disease mechanisms. Ma M, et al. Trends Genet, 2022 Sep. PMID 35484057, Free PMC Article
    4. Pathways to neurodegeneration: lessons learnt from unbiased genetic screens in Drosophila. Singhal N, et al. J Genet, 2018 Jul. PMID 30027908
    5. Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration. Liu L, et al. Cell, 2015 Jan 15. PMID 25594180, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Aats-met in the eye results in retinal degeneration.
      Title: Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methionine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methionyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in methionyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Methionyl-tRNA synthetase, mitochondrial
    Names
    CG31322-PA
    CG31322-PB
    CG31322-PC
    MetRS-m-PA
    MetRS-m-PB
    MetRS-m-PC
    Methionyl-tRNA synthetase
    mitochondrial methionyl-tRNA synthetase
    NP_001262564.1
    NP_001303507.1
    NP_650348.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14249043..14259991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316578.1 → NP_001303507.1  Methionyl-tRNA synthetase, mitochondrial, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KH54, Q8T0Q6, Q9VFL5
      Conserved Domains (3) summary
      cd00814
      Location:20 → 356
      MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
      PRK11893
      Location:21 → 553
      PRK11893; methionyl-tRNA synthetase; Reviewed
      cl12020
      Location:365 → 503
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    2. NM_001275635.2 → NP_001262564.1  Methionyl-tRNA synthetase, mitochondrial, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262564.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KH54, Q8T0Q6, Q9VFL5
      Conserved Domains (3) summary
      cd00814
      Location:20 → 356
      MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
      PRK11893
      Location:21 → 553
      PRK11893; methionyl-tRNA synthetase; Reviewed
      cl12020
      Location:365 → 503
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    3. NM_142091.5 → NP_650348.1  Methionyl-tRNA synthetase, mitochondrial, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650348.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KH54, Q8T0Q6, Q9VFL5
      Related
      FBpp0082356
      Conserved Domains (3) summary
      cd00814
      Location:20 → 356
      MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
      PRK11893
      Location:21 → 553
      PRK11893; methionyl-tRNA synthetase; Reviewed
      cl12020
      Location:365 → 503
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFL5.2 Q9VFL5

    Gene LinkOut

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