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    Myt1 Myt1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38649, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Myt1provided by FlyBase
    Official Full Name
    Myt1provided by FlyBase
    Primary source
    FLYBASE:FBgn0040298
    Locus tag
    Dmel_CG32417
    See related
    AllianceGenome:FB:FBgn0040298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10569; CG32417; Dmel\CG32417; dMyt1; Dmyt1; Myt; MYT 1; myt1; MYT1
    Summary
    Enables protein serine/threonine/tyrosine kinase activity. Involved in several processes, including G2/M transition of mitotic cell cycle; meiotic nuclear division; and spermatogenesis. Located in Golgi apparatus. Orthologous to human PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Myt1 in Genome Data Viewer
    Location:
    64E7-64E7; 3-15 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5777476..5779591, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5770576..5772691, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene scrawny Neighboring gene viriato Neighboring gene antisense RNA:CR45026 Neighboring gene Peptidoglycan recognition protein LD Neighboring gene Pmi Neighboring gene Cellular retinaldehyde binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila myt1 is the major cdk1 inhibitory kinase for wing imaginal disc development. Jin Z, et al. Genetics, 2008 Dec. PMID 18940789, Free PMC Article
    2. Identification of Drosophila Myt1 kinase and its role in Golgi during mitosis. Cornwell WD, et al. Cell Signal, 2002 May. PMID 11882391
    3. Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning. Hunter GL, et al. Development, 2016 Jul 1. PMID 27226324, Free PMC Article
    4. Aging and insulin signaling differentially control normal and tumorous germline stem cells. Kao SH, et al. Aging Cell, 2015 Feb. PMID 25470527, Free PMC Article
    5. Ecdysone signaling induces two phases of cell cycle exit in Drosophila cells. Guo Y, et al. Biol Open, 2016 Nov 15. PMID 27737823, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myt1 Kinase Couples Mitotic Cell Cycle Exit with Differentiation in Drosophila.
      Title: Myt1 Kinase Couples Mitotic Cell Cycle Exit with Differentiation in Drosophila.
    2. dMyt1 serves Cdk1 regulatory functions that are important both for normal cell-cycle progression and for coordinating mitosis with critical developmental processes
      Title: Drosophila myt1 is the major cdk1 inhibitory kinase for wing imaginal disc development.
    3. Myt1 serves unique Cdk1 regulatory functions required for efficient coupling of cell differentiation with cell cycle progression.
      Title: Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived cystoblast division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatocyte division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogonial cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Myt1
    Names
    CG32417-PA
    Myt1-PA
    NP_647987.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5777476..5779591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139730.3 → NP_647987.2  Myt1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647987.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q961T4, Q9NI63, Q9VRP6
      Related
      FBpp0076824
      Conserved Domains (2) summary
      cd14050
      Location:100 → 349
      PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
      pfam00069
      Location:102 → 349
      Pkinase; Protein kinase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NI63.2 Q9NI63

    Gene LinkOut

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