Spase12 Spase 12-subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Spase12provided by FlyBase
Official Full Name: Spase 12-subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0040623
Locus tag: Dmel_CG11500
See related: AllianceGenome:FB:FBgn0040623
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11500; CG31042; Dmel\CG11500; spase12
Summary: Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to be located in membrane. Predicted to be part of signal peptidase complex. Is expressed in adult head; embryonic/larval salivary gland; embryonic/larval salivary gland body; organism; and salivary gland body primordium. Orthologous to human SPCS1 (signal peptidase complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29490544..29491150, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25316266..25316872, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Spase12 is an essential gene required for development and cell differentiation in the fruitfly.
Title: Drosophila signal peptidase complex member Spase12 is required for development and cell differentiation.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in protein targeting to ER	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal peptide processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal peptide processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of signal peptidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of signal peptidase complex	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain