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    fne found in neurons [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32245, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fneprovided by FlyBase
    Official Full Name
    found in neuronsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086675
    Locus tag
    Dmel_CG4396
    See related
    AllianceGenome:FB:FBgn0086675
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:HL02010; BcDNA:RE25290; BEST:HL02010; cg4396; CG4396; CR32646; Dmel\CG4396; Fne; FNE; lincRNA.985; MRE28
    Old locus tag
    CR32646; Dmel_CR32646
    Summary
    Enables poly(U) RNA binding activity. Involved in male courtship behavior and regulation of mRNA processing. Located in cytoplasm. Is active in cytoplasmic ribonucleoprotein granule. Is expressed in adult brain cell body rind; adult head; and organism. Orthologous to several human genes including ELAVL2 (ELAV like RNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fne in Genome Data Viewer
    Location:
    11D3-11D4; 1-41 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12917477..12950417)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12811510..12844450)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45625 Neighboring gene long non-coding RNA:CR45626 Neighboring gene hector Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alterations of RNA-binding protein found in neurons in Drosophila neurons and glia influence synaptic transmission and lifespan. Lin WY, et al. Front Mol Neurosci, 2022. PMID 36438188, Free PMC Article
    2. A critical developmental window for ELAV/Hu-dependent mRNA signatures at the onset of neuronal differentiation. Carrasco J, et al. Cell Rep, 2022 Oct 25. PMID 36288718, Free PMC Article
    3. Characterization of fly strains permitting GAL4-directed expression of found in neurons. Chalvet F, et al. Genesis, 2002 Sep-Oct. PMID 12324951
    4. found in neurons, a third member of the Drosophila elav gene family, encodes a neuronal protein and interacts with elav. Samson ML, et al. Mech Dev, 2003 Mar. PMID 12591606
    5. Elav-Mediated Exon Skipping and Alternative Polyadenylation of the Dscam1 Gene Are Required for Axon Outgrowth. Zhang Z, et al. Cell Rep, 2019 Jun 25. PMID 31242415, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth.
      Title: The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth.
    2. ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue.
      Title: ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue.
    3. Fne null mutant males have reduced courtship indices and disrupted brain anatomy.
      Title: Deletion of the Drosophila neuronal gene found in neurons disrupts brain anatomy and male courtship.
    4. We a gene encoding a new ELAV paralogue. We showed that FNE binds RNA in vitro. fne transcripts are present throughout development and contain long UTR. Transcripts and proteins are restricted to neurons of the CNS and PNS during embryogenesis
      Title: found in neurons, a third member of the Drosophila elav gene family, encodes a neuronal protein and interacts with elav.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of RNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    found in neurons
    Names
    CG4396-PA
    CG4396-PB
    CG4396-PC
    CG4396-PD
    CG4396-PE
    CG4396-PG
    CG4396-PH
    CG4396-PI
    CG4396-PJ
    CG4396-PK
    CG4396-PL
    CR32646
    fne-PA
    fne-PB
    fne-PC
    fne-PD
    fne-PE
    fne-PG
    fne-PH
    fne-PI
    fne-PJ
    fne-PK
    fne-PL

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12917477..12950417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258718.3 → NP_001245647.1  found in neurons, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245647.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZB4
      Conserved Domains (1) summary
      TIGR01661
      Location:23 → 351
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    2. NM_001258717.1 → NP_001245646.1  found in neurons, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245646.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NGV0, Q9VYI0
      Conserved Domains (1) summary
      TIGR01661
      Location:23 → 354
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    3. NM_001258719.2 → NP_001245648.1  found in neurons, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245648.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NGV0, Q9VYI0
      Conserved Domains (1) summary
      TIGR01661
      Location:23 → 354
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    4. NM_001414105.1 → NP_001401059.1  found in neurons, isoform L [Drosophila melanogaster]

      Status: REVIEWED

    5. NM_001414104.1 → NP_001401058.1  found in neurons, isoform K [Drosophila melanogaster]

      Status: REVIEWED

    6. NM_001258720.3 → NP_001245649.2  found in neurons, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245649.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZB4
      Conserved Domains (1) summary
      TIGR01661
      Location:23 → 351
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    7. NM_001272569.1 → NP_001259498.1  found in neurons, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259498.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NGV0, Q9VYI0
      Conserved Domains (1) summary
      TIGR01661
      Location:23 → 354
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    8. NM_001103495.5 → NP_001096965.1  found in neurons, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096965.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NGV0, Q9VYI0
      Conserved Domains (1) summary
      TIGR01661
      Location:23 → 354
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    9. NM_132614.6 → NP_572842.1  found in neurons, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572842.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NGV0, Q9VYI0
      Related
      FBpp0073543
      Conserved Domains (1) summary
      TIGR01661
      Location:23 → 354
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    10. NM_001272568.2 → NP_001259497.1  found in neurons, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259497.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NGV0, Q9VYI0
      Conserved Domains (1) summary
      TIGR01661
      Location:23 → 354
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    11. NM_001298244.1 → NP_001285173.1  found in neurons, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285173.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZB4
      Conserved Domains (1) summary
      TIGR01661
      Location:23 → 351
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1NZB4 E1NZB4
    Q9VYI0 Q9VYI0

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