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    modSP modular serine protease [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42032, updated on 9-Dec-2024

    Summary

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    Official Symbol
    modSPprovided by FlyBase
    Official Full Name
    modular serine proteaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051217
    Locus tag
    Dmel_CG31217
    See related
    AllianceGenome:FB:FBgn0051217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10100; CG17557; CG31217; CT28389; Dm-SP; Dmel\CG31217; LDL; Ldlr; ModSP; Ser89E; SP172; SP53; Tep6; W; X
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in several processes, including Toll receptor ligand protein activation cascade; defense response to other organism; and positive regulation of melanization defense response. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See modSP in Genome Data Viewer
    Location:
    89D6-89D6; 3-59 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16652446..16655662, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12478168..12481384, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Methyltransferase like 4 Neighboring gene Ultrabithorax Neighboring gene antisense RNA:PS4 Neighboring gene bithoraxoid Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Clustering of peptidoglycan recognition protein-SA is required for sensing lysine-type peptidoglycan in insects. Park JW, et al. Proc Natl Acad Sci U S A, 2007 Apr 17. PMID 17409189, Free PMC Article
    2. Sexual dimorphism in Drosophila melanogaster survival of Beauveria bassiana infection depends on core immune signaling. Shahrestani P, et al. Sci Rep, 2018 Aug 21. PMID 30131599, Free PMC Article
    3. Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster. Iatsenko I, et al. Proc Natl Acad Sci U S A, 2020 Mar 31. PMID 32188787, Free PMC Article
    4. Evolution of the homeobox complex in the Diptera. Lewis EB, et al. Curr Biol, 2003 Aug 5. PMID 12906807
    5. Spätzle-Processing Enzyme-independent Activation of the Toll Pathway in Drosophila Innate Immunity. Yamamoto-Hino M, et al. Cell Struct Funct, 2016 May 7. PMID 26843333

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results demonstrate the essential role of CG31217 serine protease, named ModSP (for modular serine protease), in the activation of the Toll pathway by gram-positive bacteria and fungi.
      Title: A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll receptor ligand protein activation cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Toll receptor ligand protein activation cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Toll receptor ligand protein activation cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of melanization defense response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in receptor guanylyl cyclase signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    modular serine protease
    Names
    CG31217-PA
    low density lipoprotein receptor-like 'a' repeats
    modSP-PA
    predicted gene W
    predicted gene X
    serine protease like 89E
    serine protease-like
    NP_536776.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16652446..16655662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080515.3 → NP_536776.2  modular serine protease [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536776.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NP02, Q9VER6
      Related
      FBpp0082798
      Conserved Domains (6) summary
      cd00033
      Location:251 → 284
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00192
      Location:27 → 58
      LDLa; Low-density lipoprotein receptor domain class A
      smart00020
      Location:371 → 616
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:167 → 199
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00084
      Location:309 → 354
      Sushi; Sushi repeat (SCR repeat)
      cl21584
      Location:371 → 591
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24110 Q24110
    Q24111 Q24111
    Q9VER6.2 Q9VER6

    Gene LinkOut

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