Ephrin ephrin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ephrinprovided by FlyBase
Official Full Name: ephrinprovided by FlyBase
Primary source: FLYBASE:FBgn0040324
Locus tag: Dmel_CG1862
See related: AllianceGenome:FB:FBgn0040324
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1862; Dmel\CG1862; ephrin; lincRNA.922
Summary: Enables ephrin receptor binding activity. Involved in melanotic encapsulation of foreign target and nervous system development. Located in plasma membrane. Is expressed in several structures, including eye disc posterior to the morphogenetic furrow; larval central nervous system; mesoderm; presumptive embryonic/larval central nervous system; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in colon carcinoma; colorectal carcinoma; craniofrontonasal syndrome; dysostosis; and esophagus squamous cell carcinoma. Orthologous to several human genes including EFNB1 (ephrin B1); EFNB2 (ephrin B2); and EFNB3 (ephrin B3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (571755..580122)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (592381..600748)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ephrin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ephrin receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanotic encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

Names: CG1862-PA; CG1862-PB; CG1862-PC; Ephrin-PA; Ephrin-PB; Ephrin-PC; dephrin

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The following sections contain reference sequences that belong to a specific genome build. Explain