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    Pop2 Pop2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39366, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pop2provided by FlyBase
    Official Full Name
    Pop2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036239
    Locus tag
    Dmel_CG5684
    See related
    AllianceGenome:FB:FBgn0036239
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Caf1; CAF1; CG5684; CNOT7; Dmel\CG5684; pop2; POP2
    Summary
    Enables poly(A)-specific ribonuclease activity. Involved in negative regulation of translation and nuclear-transcribed mRNA poly(A) tail shortening. Located in cytoplasm. Part of CCR4-NOT complex. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic/larval midgut primordium; ganglia; and head epidermis primordium. Used to study heart disease. Orthologous to several human genes including CNOT7 (CCR4-NOT transcription complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Pop2 in Genome Data Viewer
    Location:
    68F1-68F1; 3-38 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11998398..12002915, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11991498..11996015, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Grip163 Neighboring gene viral IAP-associated factor Neighboring gene uncharacterized protein Neighboring gene rolling pebbles Neighboring gene long non-coding RNA:CR43994

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibiting transcription in cultured metazoan cells with actinomycin D to monitor mRNA turnover. Lai WS, et al. Methods, 2019 Feb 15. PMID 30625384, Free PMC Article
    2. Identification of transcriptional and metabolic programs related to mammalian cell size. Miettinen TP, et al. Curr Biol, 2014 Mar 17. PMID 24613310, Free PMC Article
    3. CCR4 and CAF1 deadenylases have an intrinsic activity to remove the post-poly(A) sequence. Niinuma S, et al. RNA, 2016 Oct. PMID 27484313, Free PMC Article
    4. Regulation of the Drosophila transcriptome by Pumilio and the CCR4-NOT deadenylase complex. Haugen RJ, et al. RNA, 2024 Jun 17. PMID 38627019,
    5. Defining an evolutionarily conserved role of GW182 in circular RNA degradation. Jia R, et al. Cell Discov, 2019. PMID 31636958, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A)-specific ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(A)-specific ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A)-specific ribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CCR4-NOT complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of CCR4-NOT complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    Pop2
    Names
    CG5684-PA
    CG5684-PB
    CG5684-PC
    CG5684-PD
    CG5684-PE
    CG5684-PG
    Pop2-PA
    Pop2-PB
    Pop2-PC
    Pop2-PD
    Pop2-PE
    Pop2-PG
    NP_001163429.1
    NP_001287041.1
    NP_001369048.1
    NP_648538.1
    NP_729775.1
    NP_729776.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11998398..12002915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382181.1 → NP_001369048.1  Pop2, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q6V5, Q8IGD6
      Conserved Domains (1) summary
      cl23804
      Location:25 → 291
      CAF1; CAF1 family ribonuclease

    2. NM_140281.3 → NP_648538.1  Pop2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648538.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGD6, Q961U5, Q9VTS4
      Related
      FBpp0075790
      Conserved Domains (1) summary
      cl23804
      Location:25 → 291
      CAF1; CAF1 family ribonuclease

    3. NM_168485.2 → NP_729776.1  Pop2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I0I5, Q8IGD6
      Related
      FBpp0075792
      Conserved Domains (1) summary
      cl23804
      Location:21 → 287
      CAF1; CAF1 family ribonuclease

    4. NM_168484.2 → NP_729775.1  Pop2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729775.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I0I5, Q8IGD6
      Related
      FBpp0075791
      Conserved Domains (1) summary
      cl23804
      Location:21 → 287
      CAF1; CAF1 family ribonuclease

    5. NM_001300112.1 → NP_001287041.1  Pop2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287041.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCC3
      Conserved Domains (1) summary
      cl23804
      Location:25 → 257
      CAF1; CAF1 family ribonuclease

    6. NM_001169958.3 → NP_001163429.1  Pop2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163429.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHY7
      Conserved Domains (1) summary
      cl23804
      Location:21 → 253
      CAF1; CAF1 family ribonuclease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6M3Q6V5 A0A6M3Q6V5
    E1JHY7 E1JHY7
    Q8I0I5 Q8I0I5
    Q8IGD6 Q8IGD6
    Q8MR41 Q8MR41
    Q9VTS4 Q9VTS4
    X2JCC3 X2JCC3

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