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    sol small optic lobes [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44014, updated on 9-Dec-2024

    Summary

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    Official Symbol
    solprovided by FlyBase
    Official Full Name
    small optic lobesprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003464
    Locus tag
    Dmel_CG1391
    See related
    AllianceGenome:FB:FBgn0003464
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    calp D; calpD; CalpD; CG1391; Dmel\CG1391; DmSol; nofE; PC79; Sol; SOL; w5000
    Summary
    Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Involved in nervous system development. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to human CAPN15 (calpain 15). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sol in Genome Data Viewer
    Location:
    19F5-19F5; 1-65 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21350280..21357912)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21221307..21228939)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene flightless I Neighboring gene dodo Neighboring gene penguin Neighboring gene Septin 1 Neighboring gene waclaw Neighboring gene bobby sox Neighboring gene antisense RNA:CR45612

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and analysis of small optic lobes, a structural brain gene of Drosophila melanogaster. Delaney SJ, et al. Proc Natl Acad Sci U S A, 1991 Aug 15. PMID 1714593, Free PMC Article
    2. Phototactic and geotactic behavior of countercurrent defective mutants of Drosophila melanogaster. Markow TA, et al. Behav Genet, 1977 Nov. PMID 414732
    3. Structure and physiology of calpain, an enigmatic protease. Ono Y, et al. Biochem Biophys Res Commun, 1998 Apr 17. PMID 9571143
    4. CalpA, a Drosophila calpain homolog specifically expressed in a small set of nerve, midgut, and blood cells. Theopold U, et al. Mol Cell Biol, 1995 Feb. PMID 7823949, Free PMC Article
    5. Cell degeneration in the developing optic lobes of the sine oculis and small-optic-lobes mutants of Drosophila melanogaster. Fischbach KF, et al. Dev Biol, 1984 Jul. PMID 6428950

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-dependent cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small optic lobes
    Names
    CG1391-PA
    CG1391-PB
    CG1391-PE
    CG1391-PF
    small optic lobe
    sol-PA
    sol-PB
    sol-PE
    sol-PF
    NP_996524.2
    • non-AUG (UUG) translation initiation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21350280..21357912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057390.6 → NP_476738.3  small optic lobes, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476738.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61346, P27398, Q7KU57, Q7KU58, Q8MQP3, Q9VRH3, Q9VRH4
      Related
      FBpp0088620
      Conserved Domains (4) summary
      smart00230
      Location:1001 → 1328
      CysPc; Calpain-like thiol protease family
      sd00025
      Location:647 → 667
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00029
      Location:708 → 727
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:927 → 954
      zf-RanBP; Zn-finger in Ran binding protein and others

    2. NM_001169342.2 → NP_001162813.1  small optic lobes, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162813.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ98
      Conserved Domains (4) summary
      smart00230
      Location:1000 → 1327
      CysPc; Calpain-like thiol protease family
      sd00025
      Location:647 → 667
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00029
      Location:707 → 726
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:926 → 953
      zf-RanBP; Zn-finger in Ran binding protein and others

    3. NM_057389.6 → NP_476737.3  small optic lobes, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476737.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P27398
      Related
      FBpp0088621
      Conserved Domains (2) summary
      sd00029
      Location:10 → 29
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:6 → 34
      zf-RanBP; Zn-finger in Ran binding protein and others

    4. NM_206801.3 → NP_996524.2  small optic lobes, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996524.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P27398
      Conserved Domains (4) summary
      smart00230
      Location:922 → 1249
      CysPc; Calpain-like thiol protease family
      sd00025
      Location:568 → 588
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00029
      Location:629 → 648
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:848 → 875
      zf-RanBP; Zn-finger in Ran binding protein and others
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJ98 E1JJ98
    P27398.2 P27398

    Gene LinkOut

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