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    Arp10 Actin-related protein 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32969, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arp10provided by FlyBase
    Official Full Name
    Actin-related protein 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0031050
    Locus tag
    Dmel_CG12235
    See related
    AllianceGenome:FB:FBgn0031050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Arp11; ARP11; CG12235; Dmel\CG12235
    Summary
    Involved in microtubule-based movement. Predicted to be part of dynactin complex. Predicted to be active in actin cytoskeleton. Is expressed in adult head and adult heart. Orthologous to human ACTR10 (actin related protein 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Arp10 in Genome Data Viewer
    Location:
    18D12-18D12; 1-63 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19644531..19646176, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19538564..19540209, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sec61 gamma subunit Neighboring gene Ranbp21 Neighboring gene elys

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Burst of Genetic Innovation in Drosophila Actin-Related Proteins for Testis-Specific Function. Schroeder CM, et al. Mol Biol Evol, 2020 Mar 1. PMID 31697328, Free PMC Article
    2. Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein. Hammesfahr B, et al. BMC Evol Biol, 2012 Jun 22. PMID 22726940, Free PMC Article
    3. The diaphanous gene of Drosophila interacts antagonistically with multiple wing hairs and plays a key role in wing hair morphogenesis. Lu Q, et al. PLoS One, 2015. PMID 25730111, Free PMC Article
    4. Multiple classes of MSL binding sites target dosage compensation to the X chromosome of Drosophila. Oh H, et al. Curr Biol, 2004 Mar 23. PMID 15043812
    5. Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1. Eckley DM, et al. Mol Biol Cell, 2003 Jul. PMID 12857853, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional assay for CG12235: Arp11 significantly decreases formation of organized Arp1 assemblies in cultured cells.
      Title: Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retrograde axonal transport of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynactin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Actin-related protein 10
    Names
    Arp10-PA
    Arp10-PB
    Arp11
    CG12235-PA
    CG12235-PB
    actin related protein 11

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19644531..19646176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298523.1 → NP_001285452.1  Actin-related protein 10, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285452.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWE8
      Conserved Domains (2) summary
      smart00268
      Location:11 → 340
      ACTIN; Actin
      cl17037
      Location:12 → 367
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. NM_134494.3 → NP_608338.1  Actin-related protein 10, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608338.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWE8
      Related
      FBpp0074529
      Conserved Domains (2) summary
      smart00268
      Location:11 → 340
      ACTIN; Actin
      cl17037
      Location:12 → 367
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWE8 Q9VWE8

    Gene LinkOut

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