por porcupine [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: porprovided by FlyBase
Official Full Name: porcupineprovided by FlyBase
Primary source: FLYBASE:FBgn0004957
Locus tag: Dmel_CG6205
See related: AllianceGenome:FB:FBgn0004957
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 15175; CG6205; Dmel\CG6205; dmPorc; l(1)17Ac; poc; Por; porc; Porc
Summary: Enables Wnt-protein binding activity and acyltransferase activity, transferring groups other than amino-acyl groups. Involved in Wnt protein secretion; peptide hormone processing; and regulation of Wnt signaling pathway. Located in endoplasmic reticulum. Is expressed in organism. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Orthologous to human PORCN (porcupine O-acyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18377521..18379854, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (18271554..18273887, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables acyltransferase activity, transferring groups other than amino-acyl groups	IMP Inferred from Mutant Phenotype more info	PubMed
enables palmitoleoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoleoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Wnt protein secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in Wnt protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide hormone processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain