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    Dis3 Dis3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42900, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dis3provided by FlyBase
    Official Full Name
    Dis3provided by FlyBase
    Primary source
    FLYBASE:FBgn0039183
    Locus tag
    Dmel_CG6413
    See related
    AllianceGenome:FB:FBgn0039183
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6413; dDis3; dis3; Dmel\CG6413; dRrp44; Rrp44; taz; Taz
    Summary
    Enables RNA endonuclease activity and RNA exonuclease activity. Involved in several processes, including defense response to virus; mitotic cell cycle; and nuclear RNA surveillance. Located in nuclear lamina. Part of nuclear exosome (RNase complex). Is expressed in adult head; mesoderm; nurse cell; oocyte; and organism. Used to study multiple myeloma and primary ovarian insufficiency. Orthologous to human DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dis3 in Genome Data Viewer
    Location:
    95F13-95F14; 3-84 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24333433..24337248)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20159155..20162970)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46093 Neighboring gene BRWD3 Neighboring gene Ribosomal RNA Processing 5 Neighboring gene uncharacterized protein Neighboring gene mir-1015 stem loop Neighboring gene Myosuppressin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila gene tazman, an orthologue of the yeast exosome component Rrp44p/Dis3, is differentially expressed during development. Cairrão F, et al. Dev Dyn, 2005 Mar. PMID 15704111
    2. DIS3 Variants are Associated With Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis. Johnstone EB, et al. J Clin Endocrinol Metab, 2023 Aug 18. PMID 36869713, Free PMC Article
    3. The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease. Robinson SR, et al. Biomolecules, 2015 Jul 17. PMID 26193331, Free PMC Article
    4. Characterization of the Drosophila melanogaster Dis3 ribonuclease. Mamolen M, et al. Biochem Biophys Res Commun, 2009 Dec 18. PMID 19800864, Free PMC Article
    5. The ribonuclease Dis3 is an essential regulator of the developmental transcriptome. Hou D, et al. BMC Genomics, 2012 Aug 1. PMID 22853036, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DIS3 Variants are Associated With Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis.
      Title: DIS3 Variants are Associated With Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis.
    2. Use of RNA-seq to quantify the effect of Dis3 knockdown on microRNA expression shows that Dis3 normally regulates a small subset of microRNAs, with only 11 increasing in level >/= 2-fold and 6 decreasing in level >/= 2-fold.
      Title: The 3'-5' exoribonuclease Dis3 regulates the expression of specific microRNAs in Drosophila wing imaginal discs.
    3. Dis3 is essential for early Drosophila melanogaster development.
      Title: The ribonuclease Dis3 is an essential regulator of the developmental transcriptome.
    4. the dDis3 N-terminus is sufficient for endoribonuclease activity in vitro and that proper N-terminal domain structure is critical for activity of the full-length polypeptide.
      Title: Drosophila melanogaster Dis3 N-terminal domains are required for ribonuclease activities, nuclear localization and exosome interactions.
    5. Genome-wide analysis reveals distinct substrate specificities of Dis3, and core exosome subunits
      Title: Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits.
    6. this study broadens our mechanistic understanding of the general ribonuclease activity of Dis3 and RNR family members.
      Title: Characterization of the Drosophila melanogaster Dis3 ribonuclease.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear RNA surveillance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear mRNA surveillance of mRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nuclear lamina IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dis3
    Names
    CG6413-PA
    CG6413-PB
    Dis3 ribonuclease
    Dis3-PA
    Dis3-PB
    tazman
    NP_001262910.1
    NP_651246.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24333433..24337248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142989.4 → NP_651246.2  Dis3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651246.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960A7, Q9VC93
      Related
      FBpp0083989
      Conserved Domains (3) summary
      cd09862
      Location:9 → 203
      PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
      COG0557
      Location:249 → 945
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:474 → 802
      RNB; RNB domain

    2. NM_001275981.1 → NP_001262910.1  Dis3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262910.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960A7, Q9VC93
      Conserved Domains (3) summary
      cd09862
      Location:9 → 203
      PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
      COG0557
      Location:249 → 945
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:474 → 802
      RNB; RNB domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSY2 Q8MSY2
    Q960A7 Q960A7
    Q9BI20 Q9BI20
    Q9VC93 Q9VC93

    Gene LinkOut

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