Vmat Vesicular monoamine transporter [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vmatprovided by FlyBase
Official Full Name: Vesicular monoamine transporterprovided by FlyBase
Primary source: FLYBASE:FBgn0260964
Locus tag: Dmel_CG33528
See related: AllianceGenome:FB:FBgn0260964
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG33528; CG6119; CG6139; Dmel\CG33528; dVMAT; DVMAT; DVMAT-A; DVMAT-B; l(2)SH0459; l(2)SH2 0459; vmat; VMAT; Vmt
Summary: Enables monoamine transmembrane transporter activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; positive regulation of dopaminergic neuron differentiation; and response to rotenone. Located in neuromuscular junction and synaptic vesicle. Is expressed in several structures, including CNS perineurial glial cell; aminergic neurons; brain; medulla layer; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in Parkinson's disease; bipolar disorder; infantile parkinsonism-dystonia 2; schizophrenia; and type 1 diabetes mellitus. Orthologous to human SLC18A1 (solute carrier family 18 member A1) and SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 50A14-50B1; 2-68 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (13513132..13534251, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9400637..9421756, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study identify VMAT as an important regulator of sleep in Drosophila and demonstrate that small-molecule screens provide an effective approach to identify genes and pathways that impact adult Drosophila behavior.
Title: Small-molecule screen in adult Drosophila identifies VMAT as a regulator of sleep.
Interaction between vesicular monoamine transporter and pesticides in vivo does not increase survival of fruit flies exposed to rotenone but blocks the loss of dopaminergic neurons caused by the pesticide.
Title: The Drosophila vesicular monoamine transporter reduces pesticide-induced loss of dopaminergic neurons.
A novel mRNA splice variant of Drosophila VMAT (DVMAT-B) is expressed not in neurons but rather in a small subset of glia in the lamina of the fly's optic lobe.
Title: A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables monoamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables serotonin:sodium:chloride symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
involved_in aminergic neurotransmitter loading into synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histamine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to rotenone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: vesicular monoamine transporter

Names: CG33528-PC; CG33528-PD; CG33528-PE; CG33528-PF; Vmat-PC; Vmat-PD; Vmat-PE; Vmat-PF; drosophila vesicular monoamine transporter; lethal (2) SH0459; vesicle transporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

13513132..13534251 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274027.2 → NP_001260956.1 vesicular monoamine transporter, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260956.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86NW1, Q8IGS0

Conserved Domains (2) summary

cd06174
Location:238 → 578

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:238 → 544

MFS_1; Major Facilitator Superfamily
NM_001014526.2 → NP_001014526.1 vesicular monoamine transporter, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014526.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86NW1, Q8IGS0

Conserved Domains (2) summary

cd06174
Location:238 → 578

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:238 → 544

MFS_1; Major Facilitator Superfamily
NM_001014524.2 → NP_001014524.1 vesicular monoamine transporter, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014524.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86NW1, Q8IGS0

Conserved Domains (2) summary

cd06174
Location:238 → 578

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:238 → 544

MFS_1; Major Facilitator Superfamily
NM_001014525.3 → NP_001014525.1 vesicular monoamine transporter, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014525.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IGS0, Q8IH57

Conserved Domains (2) summary

cd06174
Location:238 → 578

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam07690
Location:238 → 544

MFS_1; Major Facilitator Superfamily