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    GABA-B-R2 metabotropic GABA-B receptor subtype 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42561, updated on 17-Dec-2024

    Summary

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    Official Symbol
    GABA-B-R2provided by FlyBase
    Official Full Name
    metabotropic GABA-B receptor subtype 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0027575
    Locus tag
    Dmel_CG6706
    See related
    AllianceGenome:FB:FBgn0027575
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    :GABA-B-R2; anon-WO0170980.58; anon-WO0170980.59; BcDNA:GH07312; CG6706; D-GABA-B-R2; D-Gaba2; D-GABA[[B]]R2; dGB2; Dmel\CG6706; GABA B R2; GABA-BR2; GABA-[[B]]R2; GABA2; GABAB(R2); GABAB-R2; GABABR-R2; GABABR2; GABA[[B]]-R2; GABA[[B]]R2; GB2; GBR; GH07312
    Summary
    Enables G protein-coupled GABA receptor activity and protein heterodimerization activity. Involved in several processes, including cellular response to mechanical stimulus; gamma-aminobutyric acid signaling pathway; and negative regulation of secretion by cell. Located in plasma membrane. Part of G protein-coupled receptor heterodimeric complex. Is expressed in several structures, including ellipsoid body layer; ganglia; optic lobe centrifugal columnar neurons; organism subdivision; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in alcohol use disorder; developmental and epileptic encephalopathy 59; and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GABA-B-R2 in Genome Data Viewer
    Location:
    93F9-93F9; 3-73 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21770333..21775840, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17596055..17601562, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bursicon Neighboring gene uncharacterized protein Neighboring gene RNA polymerase I subunit H Neighboring gene torso-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Presynaptic gain control drives sweet and bitter taste integration in Drosophila. Chu B, et al. Curr Biol, 2014 Sep 8. PMID 25131672
    2. GABA(B) receptors play an essential role in maintaining sleep during the second half of the night in Drosophila melanogaster. Gmeiner F, et al. J Exp Biol, 2013 Oct 15. PMID 24068350
    3. Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila. Martelli C, et al. Elife, 2019 Jun 10. PMID 31169499, Free PMC Article
    4. Structural basis for distinct quality control mechanisms of GABA(B) receptor during evolution. Zhang S, et al. FASEB J, 2020 Dec. PMID 33058267
    5. GABAergic lateral interactions tune the early stages of visual processing in Drosophila. Freifeld L, et al. Neuron, 2013 Jun 19. PMID 23791198, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled GABA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled GABA receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled GABA receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled GABA receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of synaptic vesicle fusion to presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in olfactory behavior IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of G protein-coupled receptor heterodimeric complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of G protein-coupled receptor heterodimeric complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metabotropic GABA-B receptor subtype 2
    Names
    CG6706-PA
    CG6706-PB
    CG6706-PC
    GABA-B-R2-PA
    GABA-B-R2-PB
    GABA-B-R2-PC
    GABA[[B]]- 2 receptor
    GABA[[B]]receptor2
    metabotropic GABA[[B]] receptor 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21770333..21775840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169968.1 → NP_732658.1  metabotropic GABA-B receptor subtype 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732658.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IN24, Q9BML6
      Related
      FBpp0083565, FBtr0084167
      Conserved Domains (3) summary
      cd06366
      Location:32 → 418
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam00003
      Location:459 → 710
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:52 → 396
      ANF_receptor; Receptor family ligand binding region

    2. NM_079714.2 → NP_524438.1  metabotropic GABA-B receptor subtype 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524438.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BML6, Q9Y133
      Related
      FBpp0083566, FBtr0084168
      Conserved Domains (3) summary
      cd06366
      Location:32 → 418
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam00003
      Location:459 → 710
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:52 → 396
      ANF_receptor; Receptor family ligand binding region

    3. NM_001300527.1 → NP_001287456.1  metabotropic GABA-B receptor subtype 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287456.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHR4, Q9BML6
      Conserved Domains (3) summary
      cd06366
      Location:32 → 418
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam00003
      Location:459 → 712
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:52 → 396
      ANF_receptor; Receptor family ligand binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHR4 A0A0B4LHR4
    Q8IN24 Q8IN24
    Q9BML6 Q9BML6
    Q9Y133 Q9Y133

    Gene LinkOut

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