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    Rtc1 Rtc1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32338, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rtc1provided by FlyBase
    Official Full Name
    Rtc1provided by FlyBase
    Primary source
    FLYBASE:FBgn0020909
    Locus tag
    Dmel_CG11130
    See related
    AllianceGenome:FB:FBgn0020909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11130; Dmel\CG11130
    Summary
    Predicted to enable RNA endonuclease activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit biogenesis. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in embryonic/larval midgut and organism. Orthologous to human RCL1 (RNA terminal phosphate cyclase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rtc1 in Genome Data Viewer
    Location:
    12B10-12C1; 1-46 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13757179..13758598)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13651212..13652631)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Programmed cell death 4 Neighboring gene antisense RNA:CR43833 Neighboring gene uncharacterized protein Neighboring gene Yolk protein 3 Neighboring gene retinal degeneration B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence homologies among the three yolk polypeptide (Yp) genes in Drosophila melanogaster. Yan YL, et al. Nucleic Acids Res, 1987 Jan 12. PMID 3029679, Free PMC Article
    2. RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. Doumanis J, et al. PLoS One, 2009 Sep 30. PMID 19789644, Free PMC Article
    3. Transcriptional response to dietary restriction in Drosophila melanogaster. Ding F, et al. J Insect Physiol, 2014 Oct. PMID 24819200, Free PMC Article
    4. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article
    5. A molecularly defined duplication set for the X chromosome of Drosophila melanogaster. Venken KJ, et al. Genetics, 2010 Dec. PMID 20876565, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Rtc1
    Names
    CG11130-PA
    Rtc1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13757179..13758598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132691.4 → NP_572919.1  Rtc1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572919.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P56175, Q95TH8, Q9VY90
      Related
      FBpp0073651
      Conserved Domains (2) summary
      cd00875
      Location:7 → 349
      RNA_Cyclase_Class_I; RNA 3' phosphate cyclase domain (class I) This subfamily of cyclase-like proteins are encoded in eukaryotic genomes. They lack a conserved catalytic histidine residue required for cyclase activity, so probably do not function as cyclases. They are ...
      TIGR03400
      Location:11 → 384
      18S_RNA_Rcl1p; 18S rRNA biogenesis protein RCL1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56175.3 P56175

    Gene LinkOut

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