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    KFase Kynurenine formamidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33907, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KFaseprovided by FlyBase
    Official Full Name
    Kynurenine formamidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0287695
    Locus tag
    Dmel_CG9542
    See related
    AllianceGenome:FB:FBgn0287695
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9542; Dmel\CG9542; Kf2
    Summary
    Enables arylformamidase activity. Predicted to be involved in tryptophan catabolic process to kynurenine. Is expressed in adult fat body. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See KFase in Genome Data Viewer
    Location:
    26D9-26D9; 2-20 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6487342..6488756, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6487342..6488756, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Sec61 alpha subunit Neighboring gene long non-coding RNA:CR45463 Neighboring gene Daxx-like protein Neighboring gene Coat Protein (coatomer) epsilon Neighboring gene PHD finger protein 5a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical and genetic characterization of kynurenine formamidase from Drosophila melanogaster. Moore GP, et al. Biochem Genet, 1978 Aug. PMID 83140
    2. Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. Han Q, et al. Biochem J, 2012 Sep 1. PMID 22690733, Free PMC Article
    3. The characterization of multiple forms of kynurenine formidase in Drosophila melanogaster. Moore GP, et al. Biochim Biophys Acta, 1975 Aug 26. PMID 50862
    4. Effect of Kynurenic Acid on Pupae Viability of Drosophila melanogaster cinnabar and cardinal Eye Color Mutants with Altered Tryptophan-Kynurenine Metabolism. Navrotskaya V, et al. Neurotox Res, 2018 Aug. PMID 29619629
    5. Extension of life span by down-regulation of enzymes catalyzing tryptophan conversion into kynurenine: Possible implications for mechanisms of aging. Oxenkrug G, et al. Exp Biol Med (Maywood), 2023 Apr. PMID 37300401, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables arylformamidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arylformamidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arylformamidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tryptophan catabolic process to kynurenine IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kynurenine formamidase
    Names
    CG9542-PA
    CG9542-PB
    KFase-PA
    KFase-PB
    formamidase
    kynurenine formamidase 2
    NP_001285676.1
    NP_609036.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6487342..6488756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298747.1 → NP_001285676.1  kynurenine formamidase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285676.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMC9
      UniProtKB/TrEMBL
      X2J8X6
      Conserved Domains (1) summary
      COG0657
      Location:67 → 297
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

    2. NM_135192.2 → NP_609036.1  kynurenine formamidase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609036.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMC9
      UniProtKB/TrEMBL
      X2J8X6
      Related
      FBpp0078895, FBtr0079265
      Conserved Domains (1) summary
      COG0657
      Location:67 → 297
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMC9.1 Q9VMC9
    X2J8X6 X2J8X6

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