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    CG32052 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326184, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG32052provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0044328
    Locus tag
    Dmel_CG32052
    See related
    AllianceGenome:FB:FBgn0044328
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aSMase; BEST:HL01355; CG8163; Dmel\CG32052; Smase
    Summary
    Predicted to enable phosphoric diester hydrolase activity. Predicted to be active in extracellular space. Is expressed in adult head and embryonic head sensory system. Orthologous to several human genes including SMPDL3B (sphingomyelin phosphodiesterase acid like 3B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG32052 in Genome Data Viewer
    Location:
    67C8-67C9; 3-31 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9787046..9808713)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9792162..9801813)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45407 Neighboring gene Anion exchanger 2 Neighboring gene Z band alternatively spliced PDZ-motif protein 67 Neighboring gene Insulin-like peptide 1 Neighboring gene Insulin-like peptide 2 Neighboring gene Insulin-like peptide 3 Neighboring gene Insulin-like peptide 4 Neighboring gene uncharacterized protein Neighboring gene Insulin-like peptide 5 Neighboring gene Inhibitor-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila simulans - Ilp2. Laskowski LF, et al. MicroPubl Biol, 2022. PMID 36468154, Free PMC Article
    2. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Brogiolo W, et al. Curr Biol, 2001 Feb 20. PMID 11250149
    3. Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila. Chen X, et al. Natl Sci Rev, 2022 Dec. PMID 36713590, Free PMC Article
    4. Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities. Zhang H, et al. Proc Natl Acad Sci U S A, 2009 Nov 17. PMID 19887630, Free PMC Article
    5. Sex- and segment-specific modulation of gene expression profiles in Drosophila. Barmina O, et al. Dev Biol, 2005 Dec 15. PMID 16269142

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoric diester hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables sphingomyelin phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG32052-PC
    CG32052-PD
    CG32052-PE
    NP_001303410.1
    NP_001303411.1
    NP_729555.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9787046..9808713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316482.1 → NP_001303411.1  uncharacterized protein Dmel_CG32052, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQD3
      Conserved Domains (1) summary
      cd00842
      Location:28 → 351
      MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain

    2. NM_001316481.1 → NP_001303410.1  uncharacterized protein Dmel_CG32052, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQD3
      Conserved Domains (1) summary
      cd00842
      Location:28 → 351
      MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain

    3. NM_168375.5 → NP_729555.4  uncharacterized protein Dmel_CG32052, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729555.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQD3
      Conserved Domains (1) summary
      cd00842
      Location:28 → 351
      MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQD3 Q8IQD3
    Q8MSD7 Q8MSD7

    Gene LinkOut

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