z zeste [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: zprovided by FlyBase
Official Full Name: zesteprovided by FlyBase
Primary source: FLYBASE:FBgn0004050
Locus tag: Dmel_CG7803
See related: AllianceGenome:FB:FBgn0004050
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7803; Dmel\CG7803; e(bx); EG:BACH59J11.3; en-bx; Z; Zeste
Summary: Enables sequence-specific DNA binding activity. Involved in heterochromatin formation; positive regulation of DNA-templated transcription; and positive regulation of gene expression. Located in nucleus and polytene chromosome interband. Is expressed in several structures, including adult brain; adult muscle system; embryonic/larval salivary gland; larval central nervous system; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 3A3-3A3; 1-1 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (2447769..2450550)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (2341802..2344583)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study found that knockdown of zeste (z), a gene encoding a sequence-specific DNA-binding protein implicated in transvection, in salivary gland cells advances the initiation of their degeneration
Title: Zeste tunes the timing of ecdysone actions in triggering programmed tissue degeneration in Drosophila.
the crystal structure of the DNA binding domain of Zeste in complex with a 19-bp DNA duplex containing the consensus recognition sequence motif.
Title: Structure of Zeste-DNA Complex Reveals a New Modality of DNA Recognition by Homeodomain-Like Proteins.
Study provides additional evidence that Zeste protein plays no role in the activation of the white gene transcription; does not rule out that the white gene enhancer is able to recruit RNAPII and function as a weak promoter
Title: Functional organization of the white gene enhancer in Drosophila melanogaster.
Polycomb group (PcG) component, Enhancer of Zeste [E(z)], a histone transferase that generates trimethylation at lysine 27 of histone H3, maintains germline identity in Drosophila adult testes
Title: A non-cell autonomous role of E(z) to prevent germ cells from turning on a somatic cell marker.
Zeste is also required for insulator bypass by the eye enhancer. Taken together, these results show that Zeste can support specific long-range interactions between enhancers and promoters.
Title: Zeste can facilitate long-range enhancer-promoter communication and insulator bypass in Drosophila melanogaster.
interaction of zeste response elements do not block yellow enhancers
Title: Interaction between zeste binding sites does not block isolated yellow enhancers in Drosophila melanogaster.
the Zeste-DNA backbone contacts all map to one face of the DNA
Title: Characterization of the extended Myb-like DNA-binding domain of trithorax group protein Zeste.
Zeste mediates Polycomb repression
Title: Zeste maintains repression of Ubx transgenes: support for a new model of Polycomb repression.
DNA-binding sites for the Zeste protein within cellular memory modules are necessary for the inheritance of active chromatin through Zeste-dependent recruitment of BRM
Title: Chromatin inheritance upon Zeste-mediated Brahma recruitment at a minimal cellular memory module.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed