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    Recs1 Recs1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41724, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Recs1provided by FlyBase
    Official Full Name
    Recs1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038209
    Locus tag
    Dmel_CG9722
    See related
    AllianceGenome:FB:FBgn0038209
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9722; Dmel\CG9722; dRECS1
    Summary
    Enables pH-gated calcium channel activity and pH-gated sodium channel activity. Involved in calcium ion transmembrane transport; positive regulation of intrinsic apoptotic signaling pathway; and sodium ion transmembrane transport. Located in Golgi apparatus. Is active in lysosomal membrane. Is expressed in adult head. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Recs1 in Genome Data Viewer
    Location:
    88A10-88A10; 3-54 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14152885..14153829, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9978607..9979551, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1. Pihán P, et al. Sci Adv, 2021 Nov 12. PMID 34767445, Free PMC Article
    2. Knockdown of the putative Lifeguard homologue CG3814 in neurons of Drosophila melanogaster. M'Angale PG, et al. Genet Mol Res, 2016 Dec 19. PMID 28002605
    3. The Evolutionary Conserved Transmembrane BAX Inhibitor Motif (TMBIM) Containing Protein Family Members 5 and 6 Are Essential for the Development and Survival of Drosophila melanogaster. Zhang L, et al. Front Cell Dev Biol, 2021. PMID 34540824, Free PMC Article
    4. Age-dependent chromosomal distribution of male-biased genes in Drosophila. Zhang YE, et al. Genome Res, 2010 Nov. PMID 20798392, Free PMC Article
    5. A cautionary note for retrocopy identification: DNA-based duplication of intron-containing genes significantly contributes to the origination of single exon genes. Zhang YE, et al. Bioinformatics, 2011 Jul 1. PMID 21551137, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pH-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pH-gated sodium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in organelle membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Recs1
    Names
    CG9722-PA
    Recs1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14152885..14153829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142084.2 → NP_650341.1  Recs1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650341.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFM3
      Related
      FBpp0082367
      Conserved Domains (1) summary
      cd10428
      Location:44 → 261
      LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFM3 Q9VFM3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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