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    ZnT41F Zinc transporter 41F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35513, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZnT41Fprovided by FlyBase
    Official Full Name
    Zinc transporter 41Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025693
    Locus tag
    Dmel_CG11163
    See related
    AllianceGenome:FB:FBgn0025693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK02137; cg11163; CG11163; CK02137; Dmel\CG11163; dZnT41F; dZNT41F; ZNT41F
    Summary
    Predicted to enable zinc ion transmembrane transporter activity. Involved in detoxification of zinc ion. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; central brain primordium; clypeo-labral primordium; embryonic/larval midgut primordium; and gut section. Orthologous to human SLC30A4 (solute carrier family 30 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ZnT41F in Genome Data Viewer
    Location:
    41F10-41F11; 2-55 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5774776..5782858, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1662281..1670363, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : PsiU2-35.45 Neighboring gene Glycoprotein 210 kDa Neighboring gene Odorant receptor 42a Neighboring gene Tetraspanin 42A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease. Chi T, et al. PLoS One, 2015. PMID 25970330, Free PMC Article
    2. A role for dZIP89B in Drosophila dietary zinc uptake reveals additional complexity in the zinc absorption process. Richards CD, et al. Int J Biochem Cell Biol, 2015 Dec. PMID 26545796
    3. Dietary zinc absorption is mediated by ZnT1 in Drosophila melanogaster. Wang X, et al. FASEB J, 2009 Aug. PMID 19325039
    4. In vivo zinc toxicity phenotypes provide a sensitized background that suggests zinc transport activities for most of the Drosophila Zip and ZnT genes. Lye JC, et al. J Biol Inorg Chem, 2013 Mar. PMID 23322169
    5. Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila. Dechen K, et al. Int J Biochem Cell Biol, 2015 Mar. PMID 25562517

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c5776711-5776656 mobile_element_type = transposon:INE-1{}5625
    • Loc: c5778967-5778803 mobile_element_type = transposon:INE-1{}5626
    • Loc: c5779020-5778968 mobile_element_type = transposon:INE-1{}5635
    • Loc: c5781383-5781260 mobile_element_type = transposon:INE-1{}5642

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IC
    Inferred by Curator
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in detoxification of zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc transporter 41F
    Names
    CG11163-PA
    CG11163-PB
    CG11163-PC
    CG11163-PD
    ZnT41F-PA
    ZnT41F-PB
    ZnT41F-PC
    ZnT41F-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5774776..5782858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165448.2 → NP_724431.1  zinc transporter 41F, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724431.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0G1
      Related
      FBpp0085392
      Conserved Domains (2) summary
      TIGR01297
      Location:142 → 495
      CDF; cation diffusion facilitator family transporter
      pfam01545
      Location:142 → 416
      Cation_efflux; Cation efflux family

    2. NM_136341.3 → NP_610185.1  zinc transporter 41F, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610185.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0G1
      Related
      FBpp0085389
      Conserved Domains (2) summary
      TIGR01297
      Location:142 → 495
      CDF; cation diffusion facilitator family transporter
      pfam01545
      Location:142 → 416
      Cation_efflux; Cation efflux family

    3. NM_165446.2 → NP_724429.1  zinc transporter 41F, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724429.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0G1
      Related
      FBpp0085390
      Conserved Domains (2) summary
      TIGR01297
      Location:142 → 495
      CDF; cation diffusion facilitator family transporter
      pfam01545
      Location:142 → 416
      Cation_efflux; Cation efflux family

    4. NM_165447.2 → NP_724430.1  zinc transporter 41F, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724430.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0G1
      Related
      FBpp0085391
      Conserved Domains (2) summary
      TIGR01297
      Location:142 → 495
      CDF; cation diffusion facilitator family transporter
      pfam01545
      Location:142 → 416
      Cation_efflux; Cation efflux family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T0G1 Q8T0G1

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