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    vsg visgun [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39137, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vsgprovided by FlyBase
    Official Full Name
    visgunprovided by FlyBase
    Primary source
    FLYBASE:FBgn0045823
    Locus tag
    Dmel_CG16707
    See related
    AllianceGenome:FB:FBgn0045823
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.164; BEST:GH15083; CG16707; Dmel\CG16707; GH15083; Vsg
    Summary
    Involved in behavioral response to ethanol; long-term memory; and regulation of cell population proliferation. Located in cytoplasmic vesicle; female germline ring canal; and somatic ring canal. Is expressed in several structures, including adult brain cell body rind; dorsal ectoderm; dorsal epidermis primordium; embryonic/larval crystal cell; and embryonic/larval garland cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 66. Orthologous to several human genes including CD164 (CD164 molecule) and CD164L2 (CD164 molecule like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See vsg in Genome Data Viewer
    Location:
    67C5-67C5; 3-31 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9714324..9717716)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9707424..9710816)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SH3 and PX domain containing 1 Neighboring gene small non-coding RNA 838 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nbs

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor. Xu Y, et al. Nature, 2022 Oct. PMID 36171290, Free PMC Article
    2. The Drosophila ortholog of the endolysosomal membrane protein, endolyn, regulates cell proliferation. Zhou GQ, et al. J Cell Biochem, 2006 Dec 1. PMID 16924678
    3. Intercellular protein movement in syncytial Drosophila follicle cells. Airoldi SJ, et al. J Cell Sci, 2011 Dec 1. PMID 22135360, Free PMC Article
    4. The Gene CG6767 Affects Olfactory Behavior in Drosophila melanogaster. Brown EB, et al. Behav Genet, 2019 May. PMID 30710192
    5. The long-term memory trace formed in the Drosophila α/β mushroom body neurons is abolished in long-term memory mutants. Akalal DB, et al. J Neurosci, 2011 Apr 13. PMID 21490205, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor.
      Title: CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor.
    2. Results demonstrate that endolyn is an evolutionarily conserved sialomucin fundamentally involved in cell proliferation in both the human and Drosophila melanogaster.
      Title: The Drosophila ortholog of the endolysosomal membrane protein, endolyn, regulates cell proliferation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in female germline ring canal IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in somatic ring canal IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    visgun
    Names
    CG16707-PA
    CG16707-PB
    CG16707-PC
    CG16707-PD
    CG16707-PE
    endolyn
    vsg-PA
    vsg-PB
    vsg-PC
    vsg-PD
    vsg-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9714324..9717716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168362.2 → NP_729534.1  visgun, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729534.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VT37
      Related
      FBpp0076129
      Conserved Domains (1) summary
      pfam05283
      Location:146 → 183
      MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin

    2. NM_168363.2 → NP_729535.1  visgun, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I0D8
      Related
      FBpp0076127
      Conserved Domains (1) summary
      pfam05283
      Location:145 → 182
      MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin

    3. NM_140092.2 → NP_648349.1  visgun, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648349.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VT37
      Related
      FBpp0076130
      Conserved Domains (1) summary
      pfam05283
      Location:146 → 183
      MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin

    4. NM_168364.2 → NP_729536.1  visgun, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729536.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I0D8
      Related
      FBpp0076128
      Conserved Domains (1) summary
      pfam05283
      Location:145 → 182
      MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin

    5. NM_001274717.1 → NP_001261646.1  visgun, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261646.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHX2
      Conserved Domains (1) summary
      pfam05283
      Location:145 → 182
      MGC-24; Multi-glycosylated core protein 24 (MGC-24), sialomucin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHX2 M9PHX2
    Q8I0D8 Q8I0D8
    Q95T68 Q95T68
    Q9VT37 Q9VT37

    Gene LinkOut

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