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    SOK2 Sok2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855030, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SOK2
    Official Full Name
    Sok2p
    Primary source
    SGD:S000004618
    Locus tag
    YMR016C
    See related
    AllianceGenome:SGD:S000004618; FungiDB:YMR016C; VEuPathDB:YMR016C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in pseudohyphal growth. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SOK2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (303236..305593, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Bud22p Neighboring gene C-22 sterol desaturase Neighboring gene Spo20p Neighboring gene Pex9p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional regulation and the diversification of metabolism in wine yeast strains. Rossouw D, et al. Genetics, 2012 Jan. PMID 22042577, Free PMC Article
    2. SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription. Ward MP, et al. Mol Cell Biol, 1995 Dec. PMID 8524252, Free PMC Article
    3. The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies. Paiva S, et al. Biochem J, 2013 Sep 15. PMID 23790185
    4. Physiological regulation of yeast cell death in multicellular colonies is triggered by ammonia. Váchová L, et al. J Cell Biol, 2005 Jun 6. PMID 15939758, Free PMC Article
    5. Evolution and phylogenetic relationships of APSES proteins from Hemiascomycetes. Ramírez-Zavala B, et al. FEMS Yeast Res, 2008 Jun. PMID 18355269

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sok2p
    NP_013729.1
    • Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; relocalizes to the cytosol in response to hypoxia; SOK2 has a paralog, PHD1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      303236..305593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182512.1 → NP_013729.1  TPA: Sok2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013729.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZJ0, P53438
      UniProtKB/TrEMBL
      B3LLR8, C8ZEM4, N1P5C1
      Conserved Domains (1) summary
      pfam04383
      Location:433 → 509
      KilA-N; KilA-N domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53438.1

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