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    EUG1 protein disulfide isomerase EUG1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EUG1
    Official Full Name
    protein disulfide isomerase EUG1
    Primary source
    SGD:S000002926
    Locus tag
    YDR518W
    See related
    AllianceGenome:SGD:S000002926; FungiDB:YDR518W; VEuPathDB:YDR518W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein disulfide isomerase activity; protein-disulfide reductase (glutathione) activity; and unfolded protein binding activity. Involved in protein folding. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome and autoimmune hepatitis. Orthologous to several human genes including PDIA3 (protein disulfide isomerase family A member 3) and PDIA4 (protein disulfide isomerase family A member 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EUG1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1478608..1480161)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative glucokinase Neighboring gene Grh1p Neighboring gene peptidylprolyl isomerase family protein FPR2 Neighboring gene Urc2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast EUG1 gene encodes an endoplasmic reticulum protein that is functionally related to protein disulfide isomerase. Tachibana C, et al. Mol Cell Biol, 1992 Oct. PMID 1406650, Free PMC Article
    2. Active site mutations in yeast protein disulfide isomerase cause dithiothreitol sensitivity and a reduced rate of protein folding in the endoplasmic reticulum. Holst B, et al. J Cell Biol, 1997 Sep 22. PMID 9298979, Free PMC Article
    3. Mutation of yeast Eug1p CXXS active sites to CXXC results in a dramatic increase in protein disulphide isomerase activity. Nørgaard P, et al. Biochem J, 2001 Aug 15. PMID 11485577, Free PMC Article
    4. Functional differences between human and yeast protein disulfide isomerase family proteins. Kimura T, et al. Biochem Biophys Res Commun, 2004 Jul 23. PMID 15219835
    5. Ero1p oxidizes protein disulfide isomerase in a pathway for disulfide bond formation in the endoplasmic reticulum. Frand AR, et al. Mol Cell, 1999 Oct. PMID 10549279

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein disulfide isomerase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein disulfide isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-disulfide reductase (glutathione) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein-disulfide reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein disulfide isomerase EUG1
    NP_010806.1
    • Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1478608..1480161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180826.1 → NP_010806.1  TPA: protein disulfide isomerase EUG1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010806.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTD9, E9P901, P32474
      UniProtKB/TrEMBL
      A6ZZA5, B3LFF2, C7GKV1, C8Z674, N1P931
      Conserved Domains (1) summary
      TIGR01130
      Location:33 → 487
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32474.1

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