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    RLI1 Fe-S cluster-binding ribosome biosynthesis protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851665, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RLI1
    Official Full Name
    Fe-S cluster-binding ribosome biosynthesis protein
    Primary source
    SGD:S000002498
    Locus tag
    YDR091C
    See related
    AllianceGenome:SGD:S000002498; FungiDB:YDR091C; VEuPathDB:YDR091C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables iron ion binding activity. Involved in several processes, including ribosome biogenesis; ribosome disassembly; and translation. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to human ABCE1 (ATP binding cassette subfamily E member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RLI1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (626708..628534, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Vtc5p Neighboring gene Ilt1p Neighboring gene E2 ubiquitin-conjugating protein UBC13 Neighboring gene aminophospholipid-translocating P4-type ATPase DNF2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly. Dong J, et al. J Biol Chem, 2004 Oct 1. PMID 15277527
    2. Structural organization of essential iron-sulfur clusters in the evolutionarily highly conserved ATP-binding cassette protein ABCE1. Barthelme D, et al. J Biol Chem, 2007 May 11. PMID 17355973
    3. Structural basis of highly conserved ribosome recycling in eukaryotes and archaea. Becker T, et al. Nature, 2012 Feb 22. PMID 22358840, Free PMC Article
    4. The Candidate Antimalarial Drug MMV665909 Causes Oxygen-Dependent mRNA Mistranslation and Synergizes with Quinoline-Derived Antimalarials. Vallières C, et al. Antimicrob Agents Chemother, 2017 Sep. PMID 28652237, Free PMC Article
    5. Cryptococcus neoformans Iron-Sulfur Protein Biogenesis Machinery Is a Novel Layer of Protection against Cu Stress. Garcia-Santamarina S, et al. mBio, 2017 Oct 31. PMID 29089435, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. When Rli1 levels were diminished, 80S ribosomes accumulated both at stop codons and in the adjoining 3'UTRs of most mRNAs; Rli1 is crucial for ribosome recycling in vivo and controls ribosome homeostasis.
      Title: Rli1/ABCE1 Recycles Terminating Ribosomes and Controls Translation Reinitiation in 3'UTRs In Vivo.
    2. Collectively, the Yae1-Lto1 complex functions as a target-specific adaptor that recruits apo-Rli1 to the generic cytosolic iron-sulfur assembly machinery.
      Title: The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion.
    3. Data indicate that Rli1p function is a primary target of ROS action.
      Title: The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species.
    4. although the Fe-S cluster is not required for the interaction of Rli1 with eRF1 or its other interacting partner, Hcr1, from the initiation complex eIF3, it is required for its activity in translation termination
      Title: The iron-sulphur protein RNase L inhibitor functions in translation termination.
    5. ribosome biogenesis and function are intimately linked to the crucial role of mitochondria in the maturation of the essential Fe/S protein Rli1p
      Title: Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosome disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational termination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translational termination IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fe-S cluster-binding ribosome biosynthesis protein
    NP_010376.3
    • Essential Fe-S protein; required for ribosome biogenesis, translation initiation/termination; facilitates binding of multifactor complex (MFC) of initiation factors to small ribosomal subunit; Dom34-Hbs1 complex and Rli1p work in dissociating inactive ribosomes, thereby facilitating translation restart; forms complex with Lto1p and Yae1p; dependency on ROS-labile FeS clusters, activity in nuclear ribosomal-subunit export impaired by mild oxidative stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      626708..628534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180399.3 → NP_010376.3  TPA: Fe-S cluster-binding ribosome biosynthesis protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010376.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS78, Q03195
      UniProtKB/TrEMBL
      A6ZY57, B3LGI0, B5VFY8, C7GVP5, C8Z509, G2WAJ6
      Conserved Domains (1) summary
      COG1245
      Location:4 → 603
      Rli1; Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03195.1

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