RAD55 putative DNA-dependent ATPase RAD55 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RAD55
Official Full Name: putative DNA-dependent ATPase RAD55
Primary source: SGD:S000002483
Locus tag: YDR076W
See related: AllianceGenome:SGD:S000002483; FungiDB:YDR076W; VEuPathDB:YDR076W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable ATP-dependent activity, acting on DNA. Predicted to contribute to crossover junction DNA endonuclease activity and four-way junction DNA binding activity. Involved in heteroduplex formation and meiotic DNA recombinase assembly. Part of Rad51C-XRCC3 complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RAD55 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (598468..599688)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Role of the Rad55-Rad57 Complex in DNA Repair.
Title: The Role of the Rad55-Rad57 Complex in DNA Repair.
The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.
Title: The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.
The data suggest a model in which Csm2-Psy3 recruit the Shu complex to homologous recombination substrates, where it interacts with Rad51 through Rad55-Rad57 to stimulate Rad51 filament assembly and stability, promoting error-free repair.
Title: The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination.
The Rad55-Rad57 heterodimer appears to have a unique function in spontaneous recombination that is not essential for DSB repair.
Title: Suppression of the double-strand-break-repair defect of the Saccharomyces cerevisiae rad57 mutant.
Rad55 and Rad57 have different roles in the recombinational repair of stalled replication forks compared with double-strand break repair.
Title: Role of the Saccharomyces cerevisiae Rad51 paralogs in sister chromatid recombination.
Rad51-independent allelic conversion and break-induced replication occur independently of Rad55, Rad57, and Dmc1 but require Rad52.
Title: Rad51-independent interchromosomal double-strand break repair by gene conversion requires Rad52 but not Rad55, Rad57, or Dmc1.
These results suggest that Rad55-S2,8,14 phosphorylation activates recombinational repair, allowing for faster recovery after genotoxic stress.
Title: Phosphorylation of Rad55 on serines 2, 8, and 14 is required for efficient homologous recombination in the recovery of stalled replication forks.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to crossover junction DNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to four-way junction DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA recombinase assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in heteroduplex formation	IDA Inferred from Direct Assay more info	PubMed
involved_in meiosis I cell cycle process	IEA Inferred from Electronic Annotation more info
involved_in meiotic DNA recombinase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic DNA recombinase assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rad51C-XRCC3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rad51C-XRCC3 complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in replication fork	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative DNA-dependent ATPase RAD55

NP_010361.3

Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

598468..599688

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180384.3 → NP_010361.3 TPA: putative DNA-dependent ATPase RAD55 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010361.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VS62, P38953

UniProtKB/TrEMBL

B3LGJ4, C7GVR1, C8Z4Z4, N1P688

Conserved Domains (1) summary

COG0467
Location:15 → 321

RAD55; RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms]