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    5'-deoxynucleotidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852544, updated on 9-Dec-2024

    Summary

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    Official Full Name
    5'-deoxynucleotidase
    Primary source
    SGD:S000000446
    Locus tag
    YBR242W
    See related
    AllianceGenome:SGD:S000000446; FungiDB:YBR242W; VEuPathDB:YBR242W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 5'-deoxynucleotidase activity and GMP 5'-nucleotidase activity. Involved in deoxyribonucleoside monophosphate catabolic process. Located in cytoplasm and nucleus. Orthologous to human HDDC2 (HD domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (704670..705386)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Thi2p Neighboring gene Vvs1p Neighboring gene UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase Neighboring gene glutathione peroxidase GPX2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and biochemical characterization of the yeast HD domain containing protein YGK1 reveals a metal-dependent nucleoside 5'-monophosphatase. Yang J, et al. Biochem Biophys Res Commun, 2018 Jun 27. PMID 29752939
    2. Heterozygous yeast deletion collection screens reveal essential targets of Hsp90. Franzosa EA, et al. PLoS One, 2011. PMID 22140548, Free PMC Article
    3. A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. Lahiri S, et al. PLoS Biol, 2014 Oct. PMID 25313861, Free PMC Article
    4. Complete DNA sequence of yeast chromosome II. Feldmann H, et al. EMBO J, 1994 Dec 15. PMID 7813418, Free PMC Article
    5. The cellular economy of the Saccharomyces cerevisiae zinc proteome. Wang Y, et al. Metallomics, 2018 Dec 12. PMID 30358795, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5'-deoxynucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-deoxynucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-deoxynucleotidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GMP 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deoxyribonucleoside monophosphate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    5'-deoxynucleotidase
    NP_009801.1
    • 5'-deoxynucleotidase involved in deoxyribonucleoside monophosphate degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential gene; YBR242W has a paralog, YGL101W, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      704670..705386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178590.1 → NP_009801.1  TPA: 5'-deoxynucleotidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009801.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQN8, P38331
      UniProtKB/TrEMBL
      A6ZLI1, B3LMS0, C7GMY9, D3UEZ0, G2W9P5, N1PAV8
      Conserved Domains (1) summary
      COG1896
      Location:44 → 231
      YfbR; 5'-deoxynucleotidase YfbR and related HD superfamily hydrolases [Nucleotide transport and metabolism, General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38331.1

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