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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856230, updated on 9-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000006318
    Locus tag
    YPR114W
    See related
    AllianceGenome:SGD:S000006318; FungiDB:YPR114W; VEuPathDB:YPR114W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in lipid homeostasis. Located in endoplasmic reticulum. Orthologous to human TLCD4 (TLC domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (753301..754248)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene RNA-binding ribosome biosynthesis protein MRD1 Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase Neighboring gene Rgc1p Neighboring gene Rrg8p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functions of Ceramide Synthase Paralogs YPR114w and YJR116w of Saccharomyces cerevisiae. Mallela SK, et al. PLoS One, 2016. PMID 26752183, Free PMC Article
    2. Checkpoint kinase interaction with DNA polymerase alpha regulates replication progression during stress. Hadjicharalambous A, et al. Wellcome Open Res, 2023. PMID 37766847, Free PMC Article
    3. A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. Lahiri S, et al. PLoS Biol, 2014 Oct. PMID 25313861, Free PMC Article
    4. Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis. Opaliński Ł, et al. Cell Rep, 2018 Nov 20. PMID 30463002, Free PMC Article
    5. Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation. Pereira F, et al. PLoS One, 2019. PMID 30682149, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Both yjr116w and ypr114w deleted mutants have fragmented vacuoles and produce less reactive oxygen species than wild type.
      Title: Functions of Ceramide Synthase Paralogs YPR114w and YJR116w of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_015439.1
    • Protein distantly similar to ceramide synthases, Lag1p and Lac1p; mutation confers sensitivity to inhibitors of sphingolipid biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      753301..754248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184211.1 → NP_015439.1  TPA: uncharacterized protein YPR114W [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015439.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4B3, Q06107
      UniProtKB/TrEMBL
      C7GXS6, N1P2B4
      Conserved Domains (1) summary
      smart00724
      Location:98 → 302
      TLC; TRAM, LAG1 and CLN8 homology domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06107.1

    Gene LinkOut

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