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    MUK1 guanine nucleotide exchange factor MUK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MUK1
    Official Full Name
    guanine nucleotide exchange factor MUK1
    Primary source
    SGD:S000005991
    Locus tag
    YPL070W
    See related
    AllianceGenome:SGD:S000005991; FungiDB:YPL070W; VEuPathDB:YPL070W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in Golgi to endosome transport; late endosome to vacuole transport via multivesicular body sorting pathway; and protein localization to endosome. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MUK1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (420948..422786)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative ubiquitin-specific protease UBP16 Neighboring gene uncharacterized protein Neighboring gene farnesyltranstransferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin binding by the CUE domain promotes endosomal localization of the Rab5 GEF Vps9. Shideler T, et al. Mol Biol Cell, 2015 Apr 1. PMID 25673804, Free PMC Article
    2. Rab5-family guanine nucleotide exchange factors bind retromer and promote its recruitment to endosomes. Bean BD, et al. Mol Biol Cell, 2015 Mar 15. PMID 25609093, Free PMC Article
    3. Rab5 GTPases are required for optimal TORC2 function. Locke MN, et al. J Cell Biol, 2019 Mar 4. PMID 30578283, Free PMC Article
    4. Vrl1 relies on its VPS9-domain to play a role in autophagy in Saccharomyces cerevisiae. Li W, et al. Cell Biol Int, 2019 Aug. PMID 31038239
    5. Functional separation of endosomal fusion factors and the class C core vacuole/endosome tethering (CORVET) complex in endosome biogenesis. Cabrera M, et al. J Biol Chem, 2013 Feb 15. PMID 23264632, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Muk1 lacks ubiquitin-binding motifs, but its fusion to the Vps9 CUE domain allows Muk1 to rescue endosome morphology & cargo trafficking that result from loss of Vps9 function caused by dysfunction of endosomal sorting complexes required for transport
      Title: Ubiquitin binding by the CUE domain promotes endosomal localization of the Rab5 GEF Vps9.
    2. Novel physical interactions between retromer and the Saccharomyces cerevisiae VPS9-domain Rab5-family guanine nucleotide exchange factors Muk1 and Vps9 promote their recruitment to endosomes.
      Title: Rab5-family guanine nucleotide exchange factors bind retromer and promote its recruitment to endosomes.
    3. Data indicate that Cells lacking both Vps9 and Muk1 closely phenocopy double and triple knock-out strains lacking Rab5 paralogs.
      Title: Vps9 family protein Muk1 is the second Rab5 guanosine nucleotide exchange factor in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to endosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide exchange factor MUK1
    NP_015255.1
    • Guanine nucleotide exchange factor (GEF); involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); specifically stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF VPS9; required for localization of the CORVET complex to endosomes; contains a VPS9 domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      420948..422786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183884.1 → NP_015255.1  TPA: guanine nucleotide exchange factor MUK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015255.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3U5, Q02866
      UniProtKB/TrEMBL
      A6ZWH9, B3LKZ9, C7GTY7, C8ZIW0, G2WPB0, N1NX87
      Conserved Domains (1) summary
      cl19569
      Location:313 → 412
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02866.1

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