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    ATG29 Atg29p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATG29
    Official Full Name
    Atg29p
    Primary source
    SGD:S000006087
    Locus tag
    YPL166W
    See related
    AllianceGenome:SGD:S000006087; FungiDB:YPL166W; VEuPathDB:YPL166W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables SNARE binding activity. Involved in autophagy of mitochondrion; cellular response to nitrogen starvation; and macroautophagy. Located in phagophore assembly site. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ATG29 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (237338..237979)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mrx4p Neighboring gene DNA-directed DNA polymerase Neighboring gene Set6p Neighboring gene mismatch repair protein MLH3 Neighboring gene Svs1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel autophagy-specific gene, ATG29. Kawamata T, et al. Biochem Biophys Res Commun, 2005 Dec 30. PMID 16289106
    2. Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae. Kabeya Y, et al. Biochem Biophys Res Commun, 2009 Nov 27. PMID 19755117
    3. Structural characterization of the Saccharomyces cerevisiae autophagy regulatory complex Atg17-Atg31-Atg29. Chew LH, et al. Autophagy, 2013 Oct. PMID 23939028, Free PMC Article
    4. Rab5-dependent autophagosome closure by ESCRT. Zhou F, et al. J Cell Biol, 2019 Jun 3. PMID 31010855, Free PMC Article
    5. Scaffolding the cup-shaped double membrane in autophagy. Bahrami AH, et al. PLoS Comput Biol, 2017 Oct. PMID 29065154, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Atg17 adopts multiple conformations in the absence of Atg31 and Atg29 suggests that the two smaller components play key roles in defining and maintaining the distinct curvature of the ternary complex
      Title: Structural characterization of the Saccharomyces cerevisiae autophagy regulatory complex Atg17-Atg31-Atg29.
    2. single-particle electron microscopy analysis of the Atg17-Atg31-Atg29 complex reveals an elongated structure with Atg29 located at the opposing ends.
      Title: Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation.
    3. Atg17-Atg29-Atg31 ternary complex acts as a functional unit for autophagosome formation.
      Title: Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae.
    4. it is proposed that Atg29 functions in autophagosome formation at the pre-autophagosomal structure in collaboration with other Atg proteins
      Title: Characterization of a novel autophagy-specific gene, ATG29.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNARE binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to nitrogen starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in piecemeal microautophagy of the nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Atg1/ULK1 kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagophore assembly site IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Atg29p
    NP_015159.1
    • Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      237338..237979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183980.1 → NP_015159.1  TPA: Atg29p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015159.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3K2, Q12092
      UniProtKB/TrEMBL
      C8ZIL2, N1P1D8
      Conserved Domains (1) summary
      pfam18388
      Location:8 → 63
      Atg29_N; Atg29 N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12092.1

    Gene LinkOut

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