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    RPS12 ribosomal 40S subunit protein S12 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854551, updated on 3-Nov-2024

    Summary

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    Official Symbol
    RPS12
    Official Full Name
    ribosomal 40S subunit protein S12
    Primary source
    SGD:S000005896
    Locus tag
    YOR369C
    See related
    AllianceGenome:SGD:S000005896; FungiDB:YOR369C; VEuPathDB:YOR369C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    A structural constituent of ribosome. Involved in maintenance of translational fidelity; maturation of SSU-rRNA; and ribosomal small subunit assembly. Part of cytosolic small ribosomal subunit. Orthologous to human RPS12 (ribosomal protein S12). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RPS12 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (1028194..1028625, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Scp1p Neighboring gene Rad17p Neighboring gene GTPase-activating protein MRS6 Neighboring gene Gpb1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of the 40S beak ribosomal protein eS12 in ribosome biogenesis and function in Saccharomyces cerevisiae. Martín-Villanueva S, et al. RNA Biol, 2020 Sep. PMID 32408794, Free PMC Article
    2. RPS12 and UBC4 Are Related to Senescence Signal Production in the Ribosomal RNA Gene Cluster. Yanagi S, et al. Mol Cell Biol, 2022 May 19. PMID 35384721, Free PMC Article
    3. Protein topography of the 40 S ribosomal subunit from Saccharomyces cerevisiae as shown by chemical cross-linking. Yeh YC, et al. J Biol Chem, 1986 Oct 25. PMID 3533916
    4. Farnesol inhibits translation to limit growth and filamentation in C. albicans and S. cerevisiae. Egbe NE, et al. Microb Cell, 2017 Sep 4. PMID 28913344, Free PMC Article
    5. A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes. Kratzat H, et al. EMBO J, 2021 Jan 4. PMID 33289941, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RPS12 and UBC4 Are Related to Senescence Signal Production in the Ribosomal RNA Gene Cluster.
      Title: RPS12 and UBC4 Are Related to Senescence Signal Production in the Ribosomal RNA Gene Cluster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of translational fidelity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of translational fidelity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 40S subunit protein S12
    NP_015014.3
    • Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      1028194..1028625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183789.3 → NP_015014.3  TPA: ribosomal 40S subunit protein S12 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015014.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W362, P48589, Q02545
      UniProtKB/TrEMBL
      A6ZPJ7, B3LK24, C7GNQ1, C8ZHB7, G2WNM8, N1NZ10
      Conserved Domains (1) summary
      pfam01248
      Location:26 → 114
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48589.1

    Gene LinkOut

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