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    MCT1 [acyl-carrier-protein] S-malonyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854396, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MCT1
    Official Full Name
    [acyl-carrier-protein] S-malonyltransferase
    Primary source
    SGD:S000005747
    Locus tag
    YOR221C
    See related
    AllianceGenome:SGD:S000005747; FungiDB:YOR221C; VEuPathDB:YOR221C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables [acyl-carrier-protein] S-malonyltransferase activity. Involved in fatty acid metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in optic atrophy. Orthologous to human MCAT (malonyl-CoA-acyl carrier protein transacylase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MCT1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (756476..757558, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ste13p Neighboring gene Rcn2p Neighboring gene mitochondrial 2-oxodicarboxylate carrier Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Physiological function of mycobacterial mtFabD, an essential malonyl-CoA:AcpM transacylase of type 2 fatty acid synthase FASII, in yeast mct1Delta cells. Gurvitz A. Comp Funct Genomics, 2009. PMID 19859569, Free PMC Article
    2. Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae. Schneider R, et al. Curr Genet, 1997 Dec. PMID 9388293
    3. Requirements for Carnitine Shuttle-Mediated Translocation of Mitochondrial Acetyl Moieties to the Yeast Cytosol. van Rossum HM, et al. mBio, 2016 May 3. PMID 27143389, Free PMC Article
    4. Intersection of RNA processing and the type II fatty acid synthesis pathway in yeast mitochondria. Schonauer MS, et al. Mol Cell Biol, 2008 Nov. PMID 18779316, Free PMC Article
    5. ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly. Van Vranken JG, et al. Mol Cell, 2018 Aug 16. PMID 30118679, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables [acyl-carrier-protein] S-malonyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [acyl-carrier-protein] S-malonyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables [acyl-carrier-protein] S-malonyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    [acyl-carrier-protein] S-malonyltransferase
    NP_014864.4
    • Predicted malonyl-CoA:ACP transferase; putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      756476..757558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183640.3 → NP_014864.4  TPA: [acyl-carrier-protein] S-malonyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014864.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2S6, Q12283
      UniProtKB/TrEMBL
      B3LJP4, B5VSA3, C7GWG2, C8ZGX5, N1NX75
      Conserved Domains (1) summary
      COG0331
      Location:6 → 350
      FabD; Malonyl CoA-acyl carrier protein transacylase [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12283.2

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