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    WTM1 transcriptional modulator [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854405, updated on 9-Dec-2024

    Summary

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    Official Symbol
    WTM1
    Official Full Name
    transcriptional modulator
    Primary source
    SGD:S000005756
    Locus tag
    YOR230W
    See related
    AllianceGenome:SGD:S000005756; FungiDB:YOR230W; VEuPathDB:YOR230W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables transcription corepressor activity. Involved in meiotic cell cycle; protein localization to nucleus; and regulation of gene expression. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See WTM1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (770800..772113)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mcp1p Neighboring gene transcriptional modulator Neighboring gene mitogen-activated protein kinase kinase MKK1 Neighboring gene Mge1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The WTM genes in budding yeast amplify expression of the stress-inducible gene RNR3. Tringe SG, et al. Genetics, 2006 Nov. PMID 16980392, Free PMC Article
    2. Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing. Pemberton LF, et al. Mol Cell Biol, 1997 Aug. PMID 9234739, Free PMC Article
    3. Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. Kwan EX, et al. PLoS Genet, 2011 Aug. PMID 21901113, Free PMC Article
    4. Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Zhang Z, et al. Proc Natl Acad Sci U S A, 2006 Jan 31. PMID 16432237, Free PMC Article
    5. Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit. Wu X, et al. Mol Cell Biol, 2008 Dec. PMID 18838542, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wtm1 acts either as an adaptor to facilitate nuclear import of betabeta'(RNR2) by Kap122 or as an anchor to retain betabeta' in the nucleus
      Title: Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein.
    2. Thus, Wtm1 acts as a nuclear anchor to maintain nuclear localization of Rnr2/4 complexes outside of S phase. In the presence of DNA damage this association is disrupted and Rnr2/Rnr4 become cytoplasmic, where they join with Rnr1 to form an intact complex.
      Title: Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1.
    3. WTM1 amplifies transcriptional induction of RNR3 in response to replication stress and modulates expression of genes encoding other RNR subunits.
      Title: The WTM genes in budding yeast amplify expression of the stress-inducible gene RNR3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of protein location in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of silent mating-type cassette heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Rpd3L complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rpd3L-Expanded complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional modulator
    NP_014873.3
    • Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; acts as a nuclear anchor to retain the ribonucleotide reductase small subunit heterodimer, Rnr2p-Rnr4p, in the nucleus when cells are not in S phase; contains WD repeats

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      770800..772113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183649.3 → NP_014873.3  TPA: transcriptional modulator [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014873.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2T4, O00041, Q12363
      UniProtKB/TrEMBL
      A6ZP71, B3LJQ2, B5VSB1, C7GWF4, C8ZGY3, G2WNA0, N1NVW2
      Conserved Domains (2) summary
      sd00039
      Location:225 → 262
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:199 → 295
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12363.1

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