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    SMC5 DNA repair ATPase SMC5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854123, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SMC5
    Official Full Name
    DNA repair ATPase SMC5
    Primary source
    SGD:S000005394
    Locus tag
    YOL034W
    See related
    AllianceGenome:SGD:S000005394; FungiDB:YOL034W; VEuPathDB:YOL034W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATP hydrolysis activity; damaged DNA binding activity; and single-stranded DNA binding activity. Contributes to SUMO transferase activity. Involved in chromosome separation; recombinational repair; and resolution of DNA recombination intermediates. Located in nucleus. Part of Smc5-Smc6 complex. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome. Orthologous to human SMC5 (structural maintenance of chromosomes 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SMC5 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (259923..263204)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene glutamate--tRNA ligase MSE1 Neighboring gene Opi10p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic and selective DNA-binding activity of Smc5, a core component of the Smc5-Smc6 complex. Roy MA, et al. Cell Cycle, 2011 Feb 15. PMID 21293191
    2. A touching moment for Smc5/6: from ssDNA binding to repair. Ohouo PY, et al. Cell Cycle, 2011 Apr 15. PMID 21436624
    3. The importance of being Smc5/6. Watanabe Y. Nat Cell Biol, 2005 Apr. PMID 15803128
    4. Cryo-EM structure of the Smc5/6 holo-complex. Hallett ST, et al. Nucleic Acids Res, 2022 Sep 9. PMID 35993814, Free PMC Article
    5. Smc5-Smc6 complex preserves nucleolar integrity in S. cerevisiae. Torres-Rosell J, et al. Cell Cycle, 2005 Jul. PMID 15917663

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Smc5/6 complex is a DNA loop-extruding motor.
      Title: The Smc5/6 complex is a DNA loop-extruding motor.
    2. Cryo-EM structure of the Smc5/6 holo-complex.
      Title: Cryo-EM structure of the Smc5/6 holo-complex.
    3. Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes.
      Title: Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes.
    4. Smc5/6 in the rDNA modulates lifespan independently of Fob1.
      Title: Smc5/6 in the rDNA modulates lifespan independently of Fob1​.
    5. Integrative analysis reveals unique structural and functional features of the Smc5/6 complex.
      Title: Integrative analysis reveals unique structural and functional features of the Smc5/6 complex.
    6. Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
      Title: Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
    7. Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
      Title: Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
    8. Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association.
      Title: Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association.
    9. Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites.
      Title: Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites.
    10. Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction.
      Title: Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to SUMO transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in recombinational repair IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in resolution of DNA recombination intermediates IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair ATPase SMC5
    NP_014608.1
    • Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; supports nucleolar function; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      259923..263204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183288.1 → NP_014608.1  TPA: DNA repair ATPase SMC5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014608.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W231, Q08204
      UniProtKB/TrEMBL
      N1NWC8
      Conserved Domains (1) summary
      COG1196
      Location:42 → 1069
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08204.1

    Gene LinkOut

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