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    ESC8 Esc8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854143, updated on 9-Dec-2024

    Summary

    Official Symbol
    ESC8
    Official Full Name
    Esc8p
    Primary source
    SGD:S000005377
    Locus tag
    YOL017W
    See related
    AllianceGenome:SGD:S000005377; FungiDB:YOL017W; VEuPathDB:YOL017W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in heterochromatin formation and sister chromatid cohesion. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ESC8 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (292529..294673)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tos7p Neighboring gene Tlg2p Neighboring gene calmodulin-dependent protein kinase CMK2 Neighboring gene Irc10p

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    Esc8p
    NP_014625.1
    • Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      292529..294673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183271.1NP_014625.1  TPA: Esc8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014625.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W249, Q08119
      UniProtKB/TrEMBL
      A6ZNJ0