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    CMP2 calcineurin catalytic subunit A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CMP2
    Official Full Name
    calcineurin catalytic subunit A
    Primary source
    SGD:S000004521
    Locus tag
    YML057W
    See related
    AllianceGenome:SGD:S000004521; FungiDB:YML057W; VEuPathDB:YML057W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CNA2
    Summary
    Contributes to calcium-dependent protein serine/threonine phosphatase activity. Involved in cellular response to pheromone; conjugation with cellular fusion; and intracellular monoatomic ion homeostasis. Located in cytoplasm. Part of calcineurin complex. Human ortholog(s) of this gene implicated in aortic valve stenosis; developmental and epileptic encephalopathy 91; and schizophrenia. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha); PPP3CB (protein phosphatase 3 catalytic subunit beta); and PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CMP2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (160180..161994)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Hug1p Neighboring gene ribonucleotide reductase inhibiting protein SML1 Neighboring gene IMP dehydrogenase IMD4 Neighboring gene ncRNA Neighboring gene signal peptidase complex subunit SPC2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of MCNA, a gene encoding a catalytic subunit of calcineurin, in the rice blast fungus magnaporthe oryzae. Choi JH, et al. J Microbiol Biotechnol, 2009 Jan. PMID 19190403
    2. The Saccharomyces cerevisiae genes (CMP1 and CMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B. Liu Y, et al. Mol Gen Genet, 1991 May. PMID 1646387
    3. Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase. Cyert MS, et al. Proc Natl Acad Sci U S A, 1991 Aug 15. PMID 1651503, Free PMC Article
    4. Expression of the yeast calcineurin subunits CNA1 and CNA2 during growth and hyper-osmotic stress. Del Aguila EM, et al. FEMS Microbiol Lett, 2003 Apr 25. PMID 12725927
    5. Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. Nakamura T, et al. EMBO J, 1993 Nov. PMID 7693452, Free PMC Article

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to calcium-dependent protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcineurin-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcineurin-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular monoatomic ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of calcineurin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcineurin catalytic subunit A
    NP_013655.1
    • Calcineurin A; one isoform (the other is Cna1p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CMP2 has a paralog, CNA1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      160180..161994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182415.1 → NP_013655.1  TPA: calcineurin catalytic subunit A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013655.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZB7, P14747
      UniProtKB/TrEMBL
      A6ZM09, B3LLJ9, G2WJZ9, N1NZ01
      Conserved Domains (1) summary
      cd07416
      Location:95 → 423
      MPP_PP2B; PP2B, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14747.2

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