Sin3a transcriptional regulator, SIN3A (yeast) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sin3aprovided by MGI
Official Full Name: transcriptional regulator, SIN3A (yeast)provided by MGI
Primary source: MGI:MGI:107157
See related: Ensembl:ENSMUSG00000042557 AllianceGenome:MGI:107157
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sin3; mSin3A; mKIAA4126
Summary: Enables several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin binding activity; and transcription corepressor activity. Involved in several processes, including cerebral cortex neuron differentiation; negative regulation of circadian rhythm; and regulation of axon extension. Acts upstream of or within several processes, including cellular response to glucose stimulus; positive regulation of G2/M transition of mitotic cell cycle; and response to methylglyoxal. Located in kinetochore and nucleus. Part of transcription repressor complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; paraxial mesenchyme; and retina. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 17.1), thymus adult (RPKM 15.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 30.89 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (56979271..57035652)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (57071991..57128368)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The transcriptional regulator Sin3A balances IL-17A and Foxp3 expression in primary CD4 T cells.
Title: The transcriptional regulator Sin3A balances IL-17A and Foxp3 expression in primary CD4 T cells.
An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak beta-Cell Mass Acquisition.
Title: An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak β-Cell Mass Acquisition.
Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling.
Title: Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling.
The neuronal transcription factor Myt1L interacts via a conserved motif with the PAH1 domain of Sin3 to recruit the Sin3L/Rpd3L histone deacetylase complex.
Title: The neuronal transcription factor Myt1L interacts via a conserved motif with the PAH1 domain of Sin3 to recruit the Sin3L/Rpd3L histone deacetylase complex.
Coregulator Sin3a Promotes Postnatal Murine beta-Cell Fitness by Regulating Genes in Ca(2+) Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.
Title: Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca(2+) Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.
results indicate a vital role of Sin3a in safeguarding the developmental progression through the morula-to-blastocyst transition via Hdac1.
Title: Sin3a regulates the developmental progression through morula-to-blastocyst transition via Hdac1.
Sin3a interacted with Tet1 to facilitate the transcription of a set of their co-target genes in embryonic stem cells.
Title: Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency.
These findings together suggest that SIN3A has a critical role in regulation of synaptic plasticity and might act as a potential therapeutic target to rescue memory decline during amnesia and other neuropsychiatric pathologies
Title: Transcriptional co-repressor SIN3A silencing rescues decline in memory consolidation during scopolamine-induced amnesia.
Members of the SIN3A/HDAC2 corepressor complex are enriched in an extended NANOG interactome.
Title: The SIN3A/HDAC Corepressor Complex Functionally Cooperates with NANOG to Promote Pluripotency.
The co-repressor protein Sin3a is crucial for lung endoderm development. Loss of Sin3a in early foregut endoderm led to a specific and profound defect in lung development with lung buds failing to undergo branching morphogenesis and progressive atrophy of the proximal lung endoderm with complete epithelial loss at later stages of development.
Title: Sin3a regulates epithelial progenitor cell fate during lung development.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sin3a (e-PCR), detects polymorphism
- UniSTS:472919

Sin3a (e-PCR), detects polymorphism
- UniSTS:472920

AW553200 (e-PCR)
- UniSTS:163460

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription regulator inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dopamine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to tert-butyl hydroperoxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tert-butyl hydroperoxide	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stem cell population maintenance	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hormone levels	IEA Inferred from Electronic Annotation more info
involved_in regulation of hormone levels	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to methylglyoxal	IDA Inferred from Direct Assay more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Sin3-type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Sin3-type complex	ISO Inferred from Sequence Orthology more info
part_of Sin3-type complex	NAS Non-traceable Author Statement more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: paired amphipathic helix protein Sin3a

Names: histone deacetylase complex subunit Sin3a; transcriptional corepressor Sin3a; transcriptional regulator, SIN3 yeast homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110350.2 → NP_001103820.1 paired amphipathic helix protein Sin3a isoform 2

See identical proteins and their annotated locations for NP_001103820.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is longer compared to isoform 1.

Source sequence(s)

AC132406

Consensus CDS

CCDS52805.1

UniProtKB/Swiss-Prot

Q60520

Related

ENSMUSP00000130221.2, ENSMUST00000168177.8

Conserved Domains (1) summary

COG5602
Location:8 → 1217

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
NM_001110351.2 → NP_001103821.1 paired amphipathic helix protein Sin3a isoform 1

See identical proteins and their annotated locations for NP_001103821.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).

Source sequence(s)

AC132406

Consensus CDS

CCDS23216.1

UniProtKB/Swiss-Prot

Q570Z7, Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2

Related

ENSMUSP00000130641.2, ENSMUST00000167715.8

Conserved Domains (1) summary

COG5602
Location:8 → 1214

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
NM_001357754.2 → NP_001344683.1 paired amphipathic helix protein Sin3a isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).

Source sequence(s)

AC132406

Consensus CDS

CCDS23216.1

UniProtKB/Swiss-Prot

Q570Z7, Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2

Conserved Domains (1) summary

COG5602
Location:8 → 1214

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
NM_001420196.1 → NP_001407125.1 paired amphipathic helix protein Sin3a isoform 2

Status: VALIDATED

Source sequence(s)

AC132406
NM_001420197.1 → NP_001407126.1 paired amphipathic helix protein Sin3a isoform 2

Status: VALIDATED

Source sequence(s)

AC132406
NM_001420198.1 → NP_001407127.1 paired amphipathic helix protein Sin3a isoform 2

Status: VALIDATED

Source sequence(s)

AC132406
NM_001420199.1 → NP_001407128.1 paired amphipathic helix protein Sin3a isoform 1

Status: VALIDATED

Source sequence(s)

AC132406

UniProtKB/Swiss-Prot

Q570Z7, Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2
NM_001420200.1 → NP_001407129.1 paired amphipathic helix protein Sin3a isoform 1

Status: VALIDATED

Source sequence(s)

AC132406

UniProtKB/Swiss-Prot

Q570Z7, Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2

Related

ENSMUSP00000045044.6, ENSMUST00000049169.6
NM_011378.3 → NP_035508.2 paired amphipathic helix protein Sin3a isoform 1

See identical proteins and their annotated locations for NP_035508.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript but encodes the shorter isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).

Source sequence(s)

AC132406

Consensus CDS

CCDS23216.1

UniProtKB/Swiss-Prot

Q570Z7, Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2

Related

ENSMUSP00000126601.2, ENSMUST00000168678.8

Conserved Domains (1) summary

COG5602
Location:8 → 1214

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

56979271..57035652

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242683.3 → XP_011240985.1 paired amphipathic helix protein Sin3a isoform X1

See identical proteins and their annotated locations for XP_011240985.1

UniProtKB/Swiss-Prot

Q60520

Related

ENSMUSP00000128956.2, ENSMUST00000168502.8

Conserved Domains (1) summary

COG5602
Location:8 → 1217

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
XM_006510893.4 → XP_006510956.1 paired amphipathic helix protein Sin3a isoform X1

See identical proteins and their annotated locations for XP_006510956.1

UniProtKB/Swiss-Prot

Q60520

Conserved Domains (1) summary

COG5602
Location:8 → 1217

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
XM_030244150.1 → XP_030100010.1 paired amphipathic helix protein Sin3a isoform X2

UniProtKB/Swiss-Prot

Q570Z7, Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2

Conserved Domains (1) summary

COG5602
Location:8 → 1214

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
XM_011242685.4 → XP_011240987.1 paired amphipathic helix protein Sin3a isoform X1

See identical proteins and their annotated locations for XP_011240987.1

UniProtKB/Swiss-Prot

Q60520

Conserved Domains (1) summary

COG5602
Location:8 → 1217

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
XM_036154746.1 → XP_036010639.1 paired amphipathic helix protein Sin3a isoform X2

UniProtKB/Swiss-Prot

Q570Z7, Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2

Conserved Domains (1) summary

COG5602
Location:8 → 1214

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
XM_011242684.4 → XP_011240986.1 paired amphipathic helix protein Sin3a isoform X1

See identical proteins and their annotated locations for XP_011240986.1

UniProtKB/Swiss-Prot

Q60520

Conserved Domains (1) summary

COG5602
Location:8 → 1217

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
XM_006510892.5 → XP_006510955.1 paired amphipathic helix protein Sin3a isoform X1

See identical proteins and their annotated locations for XP_006510955.1

UniProtKB/Swiss-Prot

Q60520

Conserved Domains (1) summary

COG5602
Location:8 → 1217

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]