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    Tnpo2 transportin 2 (importin 3, karyopherin beta 2b) [ Mus musculus (house mouse) ]

    Gene ID: 212999, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tnpo2provided by MGI
    Official Full Name
    transportin 2 (importin 3, karyopherin beta 2b)provided by MGI
    Primary source
    MGI:MGI:2384849
    See related
    Ensembl:ENSMUSG00000031691 AllianceGenome:MGI:2384849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IPO3; TRN2; Knpb2b; Kpnb2b; 1110034O24Rik
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Acts upstream of or within negative regulation of muscle cell differentiation and protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; gallbladder; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies. Orthologous to human TNPO2 (transportin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 27.2), thymus adult (RPKM 27.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tnpo2 in Genome Data Viewer
    Location:
    8 C3; 8 41.51 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85763502..85784214)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85036873..85057585)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22148 Neighboring gene guided entry of tail-anchored proteins factor 3, ATPase Neighboring gene STARR-positive B cell enhancer ABC_E884 Neighboring gene STARR-positive B cell enhancer ABC_E8254 Neighboring gene telomerase RNA component interacting RNase Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87560506-87560689 Neighboring gene RIKEN cDNA A230103J11 gene Neighboring gene predicted gene, 25506 Neighboring gene STARR-seq mESC enhancer starr_22150 Neighboring gene F-box and WD-40 domain protein 9 Neighboring gene microRNA 7070 Neighboring gene G protein subunit gamma 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Involvement of transportin 2-mediated HuR import in muscle cell differentiation. van der Giessen K, et al. Mol Biol Cell, 2007 Jul. PMID 17475777, Free PMC Article
    2. Distinct effects of importin α2 and α4 on Oct3/4 localization and expression in mouse embryonic stem cells. Young JC, et al. FASEB J, 2011 Nov. PMID 21840941
    3. Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system. Han Y, et al. PLoS Biol, 2017 Aug. PMID 28777795, Free PMC Article
    4. RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Lo JC, et al. PLoS Genet, 2012. PMID 23055941, Free PMC Article
    5. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. essential for Hedgehog pathway activation; mediates ciliary translocation of Gli proteins
      Title: Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system.
    2. Early in muscle differentiation, HuR is localized to the nucleus of myoblasts by active Transportin 2 (TRN2)-mediated import.
      Title: Involvement of transportin 2-mediated HuR import in muscle cell differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6380

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transportin-2
    Names
    karyopherin (importin) beta 2b
    karyopherin beta-2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122843.2 → NP_001116315.1  transportin-2 isoform 1

      See identical proteins and their annotated locations for NP_001116315.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 and 7 all encode the same isoform (1).
      Source sequence(s)
      AC163703
      Consensus CDS
      CCDS22491.1
      UniProtKB/TrEMBL
      E9PV58, Q3U316
      Related
      ENSMUSP00000133076.2, ENSMUST00000166592.2
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    2. NM_001364031.1 → NP_001350960.1  transportin-2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1, 2, and 7, encodes isoform 1.
      Source sequence(s)
      AC163703, AK029774, AK155760, BQ771085, BY149255
      Consensus CDS
      CCDS22491.1
      UniProtKB/TrEMBL
      E9PV58, Q3U316
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    3. NM_001364032.1 → NP_001350961.1  transportin-2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform 2.
      Source sequence(s)
      AC163703, AK029774, AK155760, BQ771085, BY149255, BY233571, CB246525
      Consensus CDS
      CCDS90431.1
      UniProtKB/Swiss-Prot
      Q8C0U9, Q99LG2
      UniProtKB/TrEMBL
      Q3U316
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    4. NM_001364033.1 → NP_001350962.1  transportin-2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform 2.
      Source sequence(s)
      AC163703, AK029774, AK155760, BQ771085, BY149255, CB246525, CB246965
      Consensus CDS
      CCDS90431.1
      UniProtKB/Swiss-Prot
      Q8C0U9, Q99LG2
      UniProtKB/TrEMBL
      Q3U316
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    5. NM_001364034.1 → NP_001350963.1  transportin-2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform 2.
      Source sequence(s)
      AC163703, AK029774, AK155760, BQ771085, BY130364, BY149255, CB246525, CB246965
      Consensus CDS
      CCDS90431.1
      UniProtKB/Swiss-Prot
      Q8C0U9, Q99LG2
      UniProtKB/TrEMBL
      Q3U316
      Related
      ENSMUSP00000147583.2, ENSMUST00000211601.2
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    6. NM_001379096.1 → NP_001366025.1  transportin-2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 1-3, encodes isoform 1.
      Source sequence(s)
      AC163703
      UniProtKB/TrEMBL
      E9PV58, Q3U316
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    7. NM_145390.5 → NP_663365.3  transportin-2 isoform 1

      See identical proteins and their annotated locations for NP_663365.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains the 5'-most exon compared to variant 2. Variants 1-3 and 7 all encode the same isoform (1).
      Source sequence(s)
      AC163703
      Consensus CDS
      CCDS22491.1
      UniProtKB/TrEMBL
      E9PV58, Q3U316
      Related
      ENSMUSP00000091051.5, ENSMUST00000093360.12
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    RNA

    1. NR_166484.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163703

    2. NR_166485.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163703

    3. NR_166486.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163703

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85763502..85784214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312649.2 → XP_017168138.1  transportin-2 isoform X3

      UniProtKB/TrEMBL
      Q3U316
      Conserved Domains (3) summary
      COG5215
      Location:103 → 634
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:5 → 33
      HEAT; HEAT repeat [structural motif]
      pfam13646
      Location:52 → 132
      HEAT_2; HEAT repeats

    2. XM_036153866.1 → XP_036009759.1  transportin-2 isoform X2

      UniProtKB/TrEMBL
      Q3U316
      Conserved Domains (3) summary
      COG5215
      Location:103 → 634
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:5 → 33
      HEAT; HEAT repeat [structural motif]
      pfam13646
      Location:52 → 132
      HEAT_2; HEAT repeats

    3. XM_017312650.2 → XP_017168139.1  transportin-2 isoform X3

      UniProtKB/TrEMBL
      Q3U316
      Conserved Domains (3) summary
      COG5215
      Location:103 → 634
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:5 → 33
      HEAT; HEAT repeat [structural motif]
      pfam13646
      Location:52 → 132
      HEAT_2; HEAT repeats

    4. XM_011248342.4 → XP_011246644.1  transportin-2 isoform X1

      See identical proteins and their annotated locations for XP_011246644.1

      UniProtKB/Swiss-Prot
      Q8C0U9, Q99LG2
      UniProtKB/TrEMBL
      Q3U316
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    5. XM_036153865.1 → XP_036009758.1  transportin-2 isoform X1

      UniProtKB/Swiss-Prot
      Q8C0U9, Q99LG2
      UniProtKB/TrEMBL
      Q3U316
      Conserved Domains (2) summary
      COG5215
      Location:22 → 756
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:93 → 114
      HEAT; HEAT repeat [structural motif]

    RNA

    1. XR_878792.4 RNA Sequence

      Related
      ENSMUST00000210576.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LG2.1 GenPept UniProtKB/Swiss-Prot:Q99LG2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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