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    SAE3 Sae3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856479, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SAE3
    Official Full Name
    Sae3p
    Primary source
    SGD:S000001957
    Locus tag
    YHR079C-A
    See related
    AllianceGenome:SGD:S000001957; FungiDB:YHR079C-A; VEuPathDB:YHR079C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YHR079C-B
    Summary
    Involved in meiotic DNA recombinase assembly and reciprocal meiotic recombination. Located in condensed nuclear chromosome. Orthologous to human SWI5 (SWI5 homologous recombination repair protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SAE3 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    2
    Sequence:
    Chromosome: VIII; NC_001140.6 (262192..262553, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene bifunctional endoribonuclease/protein kinase IRE1 Neighboring gene Lam4p Neighboring gene Lrp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of conserved amino acid residues of Sae3 in Mei5-Sae3 complex for Dmc1 assembly in meiotic recombination. Sawant P, et al. Genes Genet Syst, 2023 Jun 23. PMID 37225456
    2. Mei5-Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA. Wei CD, et al. Nucleic Acids Res, 2024 Oct 28. PMID 39275989, Free PMC Article
    3. The budding yeast Mei5-Sae3 complex interacts with Rad51 and preferentially binds a DNA fork structure. Say AF, et al. DNA Repair (Amst), 2011 Jun 10. PMID 21543267, Free PMC Article
    4. The budding yeast mei5 and sae3 proteins act together with dmc1 during meiotic recombination. Tsubouchi H, et al. Genetics, 2004 Nov. PMID 15579681, Free PMC Article
    5. The Mei5-Sae3 protein complex mediates Dmc1 activity in Saccharomyces cerevisiae. Ferrari SR, et al. J Biol Chem, 2009 May 1. PMID 19270307, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mei5-Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA.
      Title: Mei5-Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA.
    2. The role of conserved amino acid residues of Sae3 in Mei5-Sae3 complex for Dmc1 assembly in meiotic recombination.
      Title: The role of conserved amino acid residues of Sae3 in Mei5-Sae3 complex for Dmc1 assembly in meiotic recombination.
    3. Study provides evidence that both Hop2 and Sae3 promote homolog bias through a Dmc1-mediated double-strand break repair during meiosis.
      Title: Hop2 and Sae3 Are Required for Dmc1-Mediated Double-Strand Break Repair via Homolog Bias during Meiosis.
    4. show the Mei5-Sae3 complex preferentially binds a fork-like DNA substrate to 3' overhanging DNA, single-stranded DNA or double-stranded DNA
      Title: The budding yeast Mei5-Sae3 complex interacts with Rad51 and preferentially binds a DNA fork structure.
    5. tgs1Delta cells are specifically defective in splicing SAE3 meiotic pre-mRNAs.
      Title: An essential role for trimethylguanosine RNA caps in Saccharomyces cerevisiae meiosis and their requirement for splicing of SAE3 and PCH2 meiotic pre-mRNAs.
    6. Mei5-Sae3 is a mediator of Dmc1 assembly during meiotic recombination in S. cerevisiae.
      Title: The Mei5-Sae3 protein complex mediates Dmc1 activity in Saccharomyces cerevisiae.
    7. Sae3 and the meiotic protein Mei5 are loading factors for the RecA homolog Dmc1 recombinase and the Dmc1-Mei5-Sae3 complex is integrated onto Rad51 ensembles and plays both catalytic and structural roles in interhomolog recombination during meiosis.
      Title: A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic DNA recombinase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sae3p
    NP_011947.2
    • Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      262192..262553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180026.1 → NP_011947.2  TPA: Sae3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011947.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL30, P89114
      UniProtKB/TrEMBL
      B3LSJ6, C8Z9M3, G2WFF3, N1P9E1
      Conserved Domains (1) summary
      pfam07061
      Location:11 → 90
      Swi5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P89114.2

    Gene LinkOut

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