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    Naa60 N(alpha)-acetyltransferase 60 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39142, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naa60provided by FlyBase
    Official Full Name
    N(alpha)-acetyltransferase 60provided by FlyBase
    Primary source
    FLYBASE:FBgn0036039
    Locus tag
    Dmel_CG18177
    See related
    AllianceGenome:FB:FBgn0036039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18177; DmAAF50213; Dmel\CG18177; dNaa60; dNAA60; dNatF; Hat4; NAA60; NatF
    Summary
    Enables histone H4 acetyltransferase activity and peptide alpha-N-acetyltransferase activity. Involved in N-terminal peptidyl-methionine acetylation and chromosome segregation. Predicted to be located in cytoplasm. Predicted to be active in Golgi membrane. Orthologous to human NAA60 (N-alpha-acetyltransferase 60, NatF catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Naa60 in Genome Data Viewer
    Location:
    67C5-67C5; 3-31 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9726895..9729650)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9719995..9722750)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene nbs Neighboring gene deflated Neighboring gene ATP synthase, subunit B Neighboring gene uncharacterized protein Neighboring gene mir-4986 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. Yang X, et al. Mol Cell, 2011 Oct 7. PMID 21981917
    2. Developmental roles of protein N-terminal acetylation. Silva RD, et al. Proteomics, 2015 Jul. PMID 25920796
    3. NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. Van Damme P, et al. PLoS Genet, 2011 Jul. PMID 21750686, Free PMC Article
    4. N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. Polevoda B, et al. J Mol Biol, 2003 Jan 24. PMID 12507466
    5. Evolutionary dynamics of U12-type spliceosomal introns. Lin CF, et al. BMC Evol Biol, 2010 Feb 17. PMID 20163699, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone H4 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide alpha-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N(alpha)-acetyltransferase 60
    Names
    CG18177-PA
    CG18177-PB
    CG18177-PC
    Naa60-PA
    Naa60-PB
    Naa60-PC
    NP_001137929.1
    NP_648353.3
    NP_996032.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9726895..9729650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206310.3 → NP_996032.1  N(alpha)-acetyltransferase 60, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996032.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7Z0F9, Q8IH11, Q95SX8, Q9VT42
      Conserved Domains (2) summary
      COG0456
      Location:74 → 207
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:136 → 198
      Acetyltransf_1; Acetyltransferase (GNAT) family

    2. NM_140096.5 → NP_648353.3  N(alpha)-acetyltransferase 60, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648353.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95SX8
      Related
      FBpp0088430
      Conserved Domains (2) summary
      pfam00583
      Location:115 → 177
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam13302
      Location:34 → 173
      Acetyltransf_3; Acetyltransferase (GNAT) domain

    3. NM_001144457.3 → NP_001137929.1  N(alpha)-acetyltransferase 60, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137929.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95SX8
      Conserved Domains (2) summary
      pfam00583
      Location:115 → 177
      Acetyltransf_1; Acetyltransferase (GNAT) family
      pfam13302
      Location:34 → 173
      Acetyltransf_3; Acetyltransferase (GNAT) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SX8.1 Q95SX8

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