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    CCT7 Chaperonin containing TCP1 subunit 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41054, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CCT7provided by FlyBase
    Official Full Name
    Chaperonin containing TCP1 subunit 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0037632
    Locus tag
    Dmel_CG8351
    See related
    AllianceGenome:FB:FBgn0037632
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cct7; Cct7; CG8351; Dmel\CG8351; Q9VHL2_DROME; T-cp1eta; T-cpleta; Tcp-1-eta1; tcp-1eta; Tcp-1eta; TCP1-eta; tcp1eta; TCP1eta; TCPeta
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in cytosol. Is expressed in adult brain; adult brain cell body rind; adult head; and adult heart. Used to study intrinsic cardiomyopathy and sensory peripheral neuropathy. Orthologous to human CCT7 (chaperonin containing TCP1 subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CCT7 in Genome Data Viewer
    Location:
    85B1-85B2; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8801564..8806234)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4627286..4631956)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene PFTAIRE-interacting factor 1B Neighboring gene PFTAIRE-interacting factor 1A Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 85a Neighboring gene uncharacterized protein Neighboring gene hinge2 Neighboring gene uncharacterized protein Neighboring gene aaquetzalli

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of nuclear factor κB (NF-κB) transcriptional activity via p65 acetylation by the chaperonin containing TCP1 (CCT). Pejanovic N, et al. PLoS One, 2012. PMID 22860050, Free PMC Article
    2. The role of Drosophila Merlin in spermatogenesis. Dorogova NV, et al. BMC Cell Biol, 2008 Jan 10. PMID 18186933, Free PMC Article
    3. Polycomb Requires Chaperonin Containing TCP-1 Subunit 7 for Maintaining Gene Silencing in Drosophila. Shaheen N, et al. Front Cell Dev Biol, 2021. PMID 34660585, Free PMC Article
    4. TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan. Melkani GC, et al. FEBS Lett, 2017 Nov. PMID 28963798, Free PMC Article
    5. CCT complex restricts neuropathogenic protein aggregation via autophagy. Pavel M, et al. Nat Commun, 2016 Dec 8. PMID 27929117, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    chaperonin containing TCP1 subunit 7
    Names
    CCT7-PA
    CG8351-PA
    TCP1-zeta homologue
    Tcp-1eta

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8801564..8806234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141578.2 → NP_649835.1  chaperonin containing TCP1 subunit 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649835.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHL2
      Related
      FBpp0081401
      Conserved Domains (2) summary
      cd03340
      Location:4 → 524
      TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...
      TIGR02345
      Location:2 → 524
      chap_CCT_eta; T-complex protein 1, eta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHL2 Q9VHL2

    Gene LinkOut

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